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Study · Animal study (in vivo) · cat, mouse and rat · 1993

6 results

The influence of the delta-sleep-inducing peptide on convulsive activity.

Shandra AA, Godlevskii LS, Mazarati AM, Oleshko AA, Mikhaleva II

Neuroscience and behavioral physiology1 Sept 1993Cited by 6 (Europe PMC)

PMID8232867 (opens in a new tab)DOI10.1007/bf01183011 (opens in a new tab)PepBankPUB-08232867
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cats, DSIP suppressed convulsive activity in cortical foci created by strychnine.

    In plain wordsIn cats, DSIP reduced seizure-like activity in brain areas that strychnine had made overactive.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStrychnine-induced cortical convulsive activity
    Study

    catn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The capacity of this peptide to suppress convulsive activity in foci created in the cerebral cortex by the application of strychnine has been demonstrated in experiments on cats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP determined the later development of the convulsive kindling syndrome; the abstract gives no direction.

    In plain wordsIn rats, DSIP influenced how a seizure-kindling condition developed later.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedDevelopment of convulsive kindling syndrome
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It has been established in experiments on rats that DSIP determines the later development of the convulsive kindling syndrome
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP prevented convulsions induced by bicuculline, picrotoxin and corazol.

    In plain wordsIn mice, DSIP prevented seizures caused by three different seizure-inducing drugs.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseConvulsions induced by bicuculline, picrotoxin and corazol
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    prevents the development of convulsions in mice induced by bicuculline, picrotoxin, and corazol
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In animals, DSIP had no anticonvulsant action against convulsions induced by thiosemicarbazide and strychnine.

    In plain wordsIn animals, DSIP did not protect against seizures caused by thiosemicarbazide or strychnine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeConvulsions induced by thiosemicarbazide and strychnine
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but is devoid of such action in relation to thiosemicarbazide and strychnine.
  5. 05AnimalAnimal study (in vivo)Mechanism

    The anticonvulsant action of DSIP is associated with its influence on the reticular portion of the substantia nigra.

    In plain wordsIn animals, the seizure-protective action of DSIP was linked to its effect on one brain region, the substantia nigra.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableRole of substantia nigra reticular portion in anticonvulsant action
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was demonstrated that the anticonvulsant action of DSIP is associated with its influence on the reticular portion of the substantia nigra.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 06AnimalEndogenous levelAnimal study (in vivo)Other

    The lowest level of the body's own DSIP was found in the reticular portion of the substantia nigra at the late stages of pharmacological kindling.

    In plain wordsIn animals, the body's own DSIP was lowest in one brain region late in seizure kindling.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP level in substantia nigra reticular portion during kindling
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The lowest level of this peptide itself has been discovered, in the reticular portion of the substantia nigra at the late stages of pharmacological kindling.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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