Skip to content

Study · Animal study (in vivo) · dog · 1993

5 results

Influence of endogenous cholinergic tone and alpha-adrenergic pathways on growth hormone responses to His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in the dog.

Muruais J, Peñalva A, Dieguez C, Casanueva FF

The Journal of endocrinology1 Aug 1993Cited by 5 (Europe PMC)

PMID8228729 (opens in a new tab)DOI10.1677/joe.0.1380211 (opens in a new tab)PepBankPUB-08228729
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult Beagle dogs, GHRP‑6 increased basal GH levels after dosing.

    In plain wordsIn dogs, GHRP‑6 increased growth hormone levels compared with baseline.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH level after dosing
    Study

    dogn = 10

    Adult Beagle dogs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    90 micrograms · intravenousAs given in this study (dog).

    Measurements

    GH
    2.6 micrograms/l
    baseline
    GH
    14.4 micrograms/l
    after 15 min

    Source sentences

    Summary
    In adult Beagle dogs (n = 10), GHRP-6 (90 micrograms i.v.) increased basal GH levels from 2.6 +/- 1.5 to 14.4 +/- 3.1 micrograms/l (mean +/- S.E.M.) after 15 min.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In dogs, combined GHRP‑6 and GHRH potentiated GH release.

    In plain wordsIn dogs, combined GHRP‑6 and GHRH increased growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseCombined GH peak
    Study

    dogn: not reported in source

    Adult Beagle dogs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    54 micrograms/l
    GHRP-6 and GHRH

    Source sentences

    Summary
    The combined administration of GHRP-6 and GHRH strikingly potentiated canine GH release with a peak of 54 +/- 9.0 micrograms/l (P < 0.01).

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In dogs, pyridostigmine pretreatment increased GHRP‑6-stimulated GH secretion.

    In plain wordsIn dogs, pyridostigmine increased growth hormone release after GHRP‑6 compared with GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    IncreasePyridostigmine-modified GH secretion
    Study

    dogn: not reported in source

    Adult Beagle dogs
    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Pretreatment with the cholinergic agonist pyridostigmine (30 mg per os) increased GHRP-6-stimulated GH secretion (37.9 +/- 10.1 micrograms/l P < 0.05),

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In dogs, atropine completely abolished GHRP‑6-stimulated GH secretion.

    In plain wordsIn dogs, atropine blocked the growth hormone response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseAtropine-modified GH secretion
    Study

    dogn: not reported in source

    Adult Beagle dogs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    while the muscarinic blocker atropine (100 micrograms i.v.) completely abolished (GH peak lower than 2 micrograms/l) the stimulatory action of GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 05AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In dogs, clonidine did not affect GH responses to GHRP‑6.

    In plain wordsIn dogs, clonidine did not change the growth hormone response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changeClonidine-modified GH response
    Study

    dogn: not reported in source

    Adult Beagle dogs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    On the other hand, administration of the alpha-2 adrenergic agonist clonidine (4 micrograms/kg i.v.) increased basal plasma GH levels without affecting GH responses to GHRP-6.(ABSTRACT TRUNCATED AT 250 WORDS)

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.