Skip to content

Study · Animal study (in vivo) · rat · 1993

10 results

In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds.

Maquart FX, Bellon G, Chaqour B, Wegrowski J, Patt LM, Trachy RE, Monboisse JC, Chastang F, Birembaut P, Gillery P

The Journal of clinical investigation1 Nov 1993Cited by 84 (Europe PMC)

PMID8227353 (opens in a new tab)PMCIDPMC288419 (opens in a new tab)DOI10.1172/jci116842 (opens in a new tab)PepBankPUB-08227353
Source linkPubMedAsk about this study
Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu injection gave a concentration-dependent increase of wound chamber dry weight.

    In plain wordsIn rats, GHK‑Cu injected into wound chambers raised wound chamber dry weight, more at higher concentrations.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound chamber dry weight
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    In the GHK-Cu-injected wound chambers, a concentration-dependent increase of dry weight, DNA, total protein, collagen, and glycosaminoglycan contents was found.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu injection gave a concentration-dependent increase of DNA content.

    In plain wordsIn rats, GHK‑Cu injected into wound chambers raised DNA content, more at higher concentrations.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound chamber DNA content
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    In the GHK-Cu-injected wound chambers, a concentration-dependent increase of dry weight, DNA, total protein, collagen, and glycosaminoglycan contents was found.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu injection gave a concentration-dependent increase of total protein content.

    In plain wordsIn rats, GHK‑Cu injected into wound chambers raised total protein, more at higher concentrations.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound chamber total protein
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    In the GHK-Cu-injected wound chambers, a concentration-dependent increase of dry weight, DNA, total protein, collagen, and glycosaminoglycan contents was found.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu injection gave a concentration-dependent increase of collagen content.

    In plain wordsIn rats, GHK‑Cu injected into wound chambers raised collagen content, more at higher concentrations.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound chamber collagen content
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    In the GHK-Cu-injected wound chambers, a concentration-dependent increase of dry weight, DNA, total protein, collagen, and glycosaminoglycan contents was found.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu injection gave a concentration-dependent increase of glycosaminoglycan content.

    In plain wordsIn rats, GHK‑Cu injected into wound chambers raised glycosaminoglycan content, more at higher concentrations.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound chamber glycosaminoglycan content
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    In the GHK-Cu-injected wound chambers, a concentration-dependent increase of dry weight, DNA, total protein, collagen, and glycosaminoglycan contents was found.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, the stimulation of collagen synthesis by GHK‑Cu was twice that of noncollagen proteins.

    In plain wordsIn rats, GHK‑Cu stimulated collagen synthesis in wound chambers twice as much as it stimulated other proteins.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCollagen synthesis relative to noncollagen proteins
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    The stimulation of collagen synthesis was twice that of noncollagen proteins.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu increased type I collagen mRNA.

    In plain wordsIn rats, GHK‑Cu raised type I collagen gene message in wound chambers.

    Peptide
    GHK-Cu
    Outcome
    IncreaseType I collagen mRNA
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    Type I and type III collagen mRNAs were increased but not TGF beta mRNAs.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu increased type III collagen mRNA.

    In plain wordsIn rats, GHK‑Cu raised type III collagen gene message in wound chambers.

    Peptide
    GHK-Cu
    Outcome
    IncreaseType III collagen mRNA
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    Type I and type III collagen mRNAs were increased but not TGF beta mRNAs.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu did not increase TGF beta mRNA.

    In plain wordsIn rats, GHK‑Cu did not raise TGF beta gene message in wound chambers.

    Peptide
    GHK-Cu
    Outcome
    No significant changeTGF beta mRNA
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    Type I and type III collagen mRNAs were increased but not TGF beta mRNAs.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with wound chambers, GHK‑Cu increased the relative amount of dermatan sulfate.

    In plain wordsIn rats, GHK‑Cu raised the relative amount of dermatan sulfate in wound chambers.

    Peptide
    GHK-Cu
    Outcome
    IncreaseRelative amount of dermatan sulfate
    Study

    ratn: not reported in source

    Subcutaneous wire mesh wound chamber
    Comparator
    Saline control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    various concentrations · injection into the wound chamberAs given in this study (rat).

    Source sentences

    Summary
    An increase of the relative amount of dermatan sulfate was also found.
    2 context sentences
    Summary · context
    Stainless steel wire mesh cylinders were implanted subcutaneously on the back of rats.
    Summary · context
    The animals were divided into groups that received sequential injections into the wound chamber of either saline (control group) or various concentrations of GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.