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Study · Animal study (in vivo) · mouse · 1993

4 results

Thymosin alpha 1 down-regulates the growth of human non-small cell lung cancer cells in vitro and in vivo.

Moody TW, Fagarasan M, Zia F, Cesnjaj M, Goldstein AL

Cancer research1 Nov 1993Cited by 38 (Europe PMC)

PMID8221658 (opens in a new tab)PepBankPUB-08221658
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, thymosin alpha‑1 inhibited the formation of human non-small cell lung cancer xenografts.

    In plain wordsIn mice, thymosin alpha‑1 reduced the growth of human lung cancer tumours transplanted into the mice.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseNSCLC xenograft formation
    Study

    mousen: not reported in source

    nude mice with human NSCLC xenografts
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10 micrograms/day · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Using growth assays in vivo, THN alpha 1 (10 micrograms s.c./day) but not THN1-14, THN15-28, or THN beta 4 inhibited significantly NSCLC xenograft formation in nude mice.
    1 context sentence
    Summary · context
    The effect of thymosin alpha 1 (THN alpha 1) and its NH2-terminal fragment (THN1-14) and COOH-terminal fragment (THN15-28) on non-small cell lung cancer (NSCLC) growth was evaluated.
  2. 02LabIn vitro (cells)Mechanism

    In human non-small cell lung cancer cells, thymosin alpha‑1 significantly increased the rate of arachidonic acid release.

    In plain wordsIn lung cancer cells, thymosin alpha‑1 increased the release of arachidonic acid.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseArachidonic acid release
    Study

    humann: not reported in source

    human NSCLC cells (NCI-H1299)
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    THN alpha 1 significantly increased the rate of arachidonic acid release.
    1 context sentence
    Summary · context
    The effect of thymosin alpha 1 (THN alpha 1) and its NH2-terminal fragment (THN1-14) and COOH-terminal fragment (THN15-28) on non-small cell lung cancer (NSCLC) growth was evaluated.
  3. 03LabIn vitro (cells)Mechanism

    Using an anti-thymosin alpha‑1 antibody, receptors were identified on non-small cell lung cancer cells pretreated with thymosin alpha‑1.

    In plain wordsIn lung cancer cells, tests with an antibody found receptors that bind thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableReceptor identification on NSCLC cells
    Study

    humann: not reported in source

    human NSCLC cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    10(-6) MAs given in this study (human).

    Source sentences

    Summary
    Using an anti-THN alpha 1 antibody, receptors were identified on NSCLC cells that were pretreated with 10(-6) M THN alpha 1.
    1 context sentence
    Summary · context
    The effect of thymosin alpha 1 (THN alpha 1) and its NH2-terminal fragment (THN1-14) and COOH-terminal fragment (THN15-28) on non-small cell lung cancer (NSCLC) growth was evaluated.
  4. 04LabIn vitro (cells)Efficacy outcome

    In clonogenic assays, thymosin alpha‑1 significantly decreased the colony number of non-small cell lung cancer cells.

    In plain wordsIn cells, thymosin alpha‑1 reduced the number of lung cancer cell colonies that grew.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseNSCLC colony number in vitro
    Study

    humann: not reported in source

    human NSCLC cells (clonogenic assay)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10(-6) MAs given in this study (human).

    Source sentences

    Summary
    THN alpha 1 (10(-6) M) significantly decreased NSCLC colony number
    1 context sentence
    Summary · context
    The effect of thymosin alpha 1 (THN alpha 1) and its NH2-terminal fragment (THN1-14) and COOH-terminal fragment (THN15-28) on non-small cell lung cancer (NSCLC) growth was evaluated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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