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Study · Measured the body's own peptide · 1993

2 results

Lack of circadian rhythm of plasma concentrations of vasoactive intestinal peptide in patients with orthotopic heart transplants.

Cugini P, Lucia P, Scibilia G, Di Palma L, Cioli AR, Cianetti A, Gasbarrone L, Canova R, Marino B

British heart journal1 Oct 1993Cited by 4 (Europe PMC)

PMID8217446 (opens in a new tab)PMCIDPMC1025333 (opens in a new tab)DOI10.1136/hrt.70.4.363 (opens in a new tab)PepBankPUB-08217446
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    Plasma VIP concentrations were lower in patients with orthotopic heart transplants than in healthy controls.

    In plain wordsIn people with a heart transplant, the body's own VIP level in blood was lower than in healthy people.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreasePlasma VIP concentration
    Study

    n = 23

    Comparator
    Ten healthy controls
    Outcome group
    Endogenous peptide levels · Cardiovascular

    Source sentences

    Summary
    Plasma concentrations of VIP were lower in the patients with orthotopic heart transplants than in the controls (p < 0.001).
    2 context sentences
    Summary · context
    13 patients with orthotopic heart transplants were studied 12-53 months (mean 31.8 months) after operation.
    Summary · context
    Ten healthy individuals were studied as controls.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    A significant within-day variability and circadian rhythm of plasma VIP were found in healthy controls but not in patients with heart transplants.

    In plain wordsIn people with a heart transplant, the body's own VIP level in blood showed no daily rhythm, unlike in healthy people.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeCircadian rhythm of plasma VIP
    Study

    n = 23

    Comparator
    Ten healthy controls
    Outcome group
    Endogenous peptide levels · Cardiovascular

    Source sentences

    Summary
    ANOVA and the cosinor method respectively showed a statistically significant within-day variability and circadian rhythm in the controls but not in the patients with heart transplants.
    2 context sentences
    Summary · context
    13 patients with orthotopic heart transplants were studied 12-53 months (mean 31.8 months) after operation.
    Summary · context
    Ten healthy individuals were studied as controls.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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