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Study · Randomized controlled trial · n = 14 · 1994

4 results

The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: a prospective, randomized study.

Reinsch RC, Murphy AA, Morales AJ, Yen SS

American journal of obstetrics and gynecology1 Jun 1994Cited by 56 (Europe PMC)

PMID8203418 (opens in a new tab)DOI10.1016/s0002-9378(94)70332-9 (opens in a new tab)PepBankPUB-08203418
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with fibroids, uterine volume reduction did not differ significantly between leuprolide and RU 486.

    In plain wordsUterine volume reduction did not differ significantly between leuprolide and RU 486.

    Peptide
    Leuprolide
    Outcome
    No significant changeUterine volume between treatments
    Study

    n = 14

    Comparator
    RU 486 25 mg daily
    Outcome group
    Tumor growth · Reproductive and sexual health
    Studied dose
    3.75 mg monthly · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    There was no significant decrease between groups.
    2 context sentences
    Summary · context
    We noted a significant decrease in uterine volume compared with pretreatment in both groups at 3 months.
    Summary · context
    Patients were randomly assigned to group A (eight patients) receiving 25 mg of RU 486 daily for 3 months or group B (six patients) receiving 3.75 mg of leuprolide acetate monthly for 3 months.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with fibroids, uterine artery resistive index increased during leuprolide treatment, as it also did with RU 486.

    In plain wordsUterine artery resistance increased during leuprolide treatment, as it also did with RU 486.

    Peptide
    Leuprolide
    Outcome
    IncreaseUterine artery resistive index
    Study

    n = 6

    Outcome group
    Vascular function · Reproductive and sexual health
    Studied dose
    3.75 mg monthly · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Both groups showed an increase in resistive index.
    1 context sentence
    Summary · context
    Patients were randomly assigned to group A (eight patients) receiving 25 mg of RU 486 daily for 3 months or group B (six patients) receiving 3.75 mg of leuprolide acetate monthly for 3 months.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with fibroids, uterine artery blood flow decreased by 21% during leuprolide treatment.

    In plain wordsUterine artery blood flow decreased by 21% during leuprolide treatment.

    Peptide
    Leuprolide
    Outcome
    DecreaseUterine artery blood flow
    Study

    n = 6

    Outcome group
    Vascular function · Reproductive and sexual health
    Studied dose
    3.75 mg monthly · 3 monthsAs given in this study (human).

    Measurements

    Uterine artery blood flow decrease
    21%
    leuprolide

    Source sentences

    Summary
    Patients receiving RU 486 had uterine artery blood flow decreased by 40%, and those receiving leuprolide acetate had a 21% decrease.
    1 context sentence
    Summary · context
    Patients were randomly assigned to group A (eight patients) receiving 25 mg of RU 486 daily for 3 months or group B (six patients) receiving 3.75 mg of leuprolide acetate monthly for 3 months.
  4. 04HumanNon-randomized trialEfficacy outcome

    In patients with fibroids, uterine volume decreased significantly from pretreatment at 3 months with leuprolide, as it also did with RU 486.

    In plain wordsUterine volume decreased from pretreatment at 3 months with leuprolide, as it also did with RU 486.

    Peptide
    Leuprolide
    Outcome
    DecreaseUterine volume change
    Study

    n = 6

    Outcome group
    Tumor growth · Reproductive and sexual health
    Studied dose
    3.75 mg monthly · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    We noted a significant decrease in uterine volume compared with pretreatment in both groups at 3 months.
    1 context sentence
    Summary · context
    Patients were randomly assigned to group A (eight patients) receiving 25 mg of RU 486 daily for 3 months or group B (six patients) receiving 3.75 mg of leuprolide acetate monthly for 3 months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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