The intestinal uptake of "enzymatically-stable" peptide drugs in rats as influenced by D-glucose in situ.

Hu Z, Tse EG, Monkhouse DC, Oh CK, Fleisher D

Life sciences1 Jan 1994Cited by 2 (Europe PMC)

PMID8201846DOI10.1016/0024-3205(94)90132-5PepBankPUB-08201846

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Pharmacokinetics
In rats, luminal glucose did not enhance uptake of the larger peptides, including GHRP‑6.
In plain wordsIn rats, glucose did not increase intestinal uptake of the larger peptides, including GHRP‑6.
Peptide
GHRP-6
Outcome
No significant changeJejunal GHRP-6 uptake with glucose
Study
ratn: not reported in source
in situ single-pass jejunal perfusion
Comparator
without glucose
Outcome group
Pharmacokinetics · Gastrointestinal
Source sentences
Summary
Glucose was shown to enhance the uptake of the smaller (di- and tri-) peptides but not the larger peptides despite the fact that glucose elicited a significant net water absorption with each of the four peptide drugs.
1 context sentence(design, population, supporting numbers)
Summary · context
Jejunal wall permeabilities (Pw*) of di-(D-kyotorphin), tri-(cephradine), hexa-(growth hormone releasing peptide, GHRP-6) and octa-(octreotide, a somatostatin analogue) peptides and corresponding net water fluxes were determined in rats using an in situ single-pass perfusion technique.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0820184601
02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Pharmacokinetics
In rats, glucose significantly increased net water absorption during perfusion with GHRP‑6 and each other peptide drug.
In plain wordsIn rats, glucose increased water absorption during intestinal perfusion with GHRP‑6 and the other tested peptides.
Peptide
GHRP-6
Outcome
IncreaseNet water absorption with glucose
Study
ratn: not reported in source
in situ single-pass jejunal perfusion
Outcome group
Pharmacokinetics · Gastrointestinal
Source sentences
Summary
Glucose was shown to enhance the uptake of the smaller (di- and tri-) peptides but not the larger peptides despite the fact that glucose elicited a significant net water absorption with each of the four peptide drugs.
1 context sentence(design, population, supporting numbers)
Summary · context
Jejunal wall permeabilities (Pw*) of di-(D-kyotorphin), tri-(cephradine), hexa-(growth hormone releasing peptide, GHRP-6) and octa-(octreotide, a somatostatin analogue) peptides and corresponding net water fluxes were determined in rats using an in situ single-pass perfusion technique.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0820184602

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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