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Study · In vitro (cells) · 1994

5 results

Growth hormone (GH)-releasing peptide stimulation of GH release from human somatotroph adenoma cells: interaction with GH-releasing hormone, thyrotropin-releasing hormone, and octreotide.

Renner U, Brockmeier S, Strasburger CJ, Lange M, Schopohl J, Müller OA, von Werder K, Stalla GK

The Journal of clinical endocrinology and metabolism1 May 1994Cited by 34 (Europe PMC)

PMID8175966 (opens in a new tab)DOI10.1210/jcem.78.5.8175966 (opens in a new tab)PepBankPUB-08175966
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human somatotroph adenoma cultures, GHRP stimulated GH secretion in all 12 cultures.

    In plain wordsIn cells from human pituitary tumors, GHRP increased growth hormone release in every tested culture.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH secretion
    Study

    humann = 12

    somatotroph adenoma cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GH secretion of all 12 adenoma cultures could be stimulated with GHRP, whereas GHRH was active only in 6 adenoma cultures.
    1 context sentence
    Summary · context
    To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide.
  2. 02LabIn vitro (cells)Mechanism

    In GHRH-responsive human adenoma cultures, adding GHRP to GHRH had an additive effect on GH secretion.

    In plain wordsIn cells from human pituitary tumors, adding GHRP to GHRH increased growth hormone release beyond GHRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseAddition to GHRH
    Study

    humann = 6

    somatotroph adenoma cultures
    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In GHRH-responsive cell cultures, simultaneous application of GHRH and GHRP had an additive effect on GH secretion.
    1 context sentence
    Summary · context
    To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide.
  3. 03LabIn vitro (cells)Mechanism

    In TRH-responsive human adenoma cultures, adding GHRP to TRH had an additive effect on GH secretion.

    In plain wordsIn cells from human pituitary tumors, adding GHRP to TRH increased growth hormone release beyond TRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseAddition to TRH
    Study

    humann = 4

    somatotroph adenoma cultures
    Comparator
    TRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TRH stimulated GH release in 4 of 7 adenoma cultures; in TRH-responsive cell cultures there was also an additive effect of GHRP and TRH on GH secretion.
    1 context sentence
    Summary · context
    To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In octreotide-responsive human adenoma cultures, octreotide suppressed GHRP-induced GH release.

    In plain wordsIn responsive cells from human pituitary tumors, octreotide reduced GHRP-induced growth hormone release.

    Peptide
    GHRP-6
    Outcome
    DecreaseOctreotide suppression of GHRP response
    Study

    humann = 5

    somatotroph adenoma cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In these cell cultures, GHRP-induced GH release was suppressed by octreotide.
    2 context sentences
    Summary · context
    In 5 of 9 adenoma cultures investigated, octreotide inhibited basal GH secretion.
    Summary · context
    To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In human adenoma cultures, phloretin partly inhibited GHRP-stimulated GH release in all 5 cases.

    In plain wordsIn cells from human pituitary tumors, phloretin partly reduced GHRP-induced growth hormone release in every tested case.

    Peptide
    GHRP-6
    Outcome
    DecreasePhloretin suppression of GHRP response
    Study

    humann = 5

    somatotroph adenoma cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In 5 of 5 cases, the protein kinase-C inhibitor phloretin partly inhibited GHRP-stimulated GH release, but not basal GH secretion.
    1 context sentence
    Summary · context
    To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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