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Study · Animal study (in vivo) · rat · 1994

3 results

The effect on vertebral bone mass and strength of long term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone-(1-38), and combination therapy, assessed in aged ovariectomized rats.

Mosekilde L, Danielsen CC, Gasser J

Endocrinology1 May 1994Cited by 104 (Europe PMC)

PMID8156913 (opens in a new tab)DOI10.1210/endo.134.5.8156913 (opens in a new tab)PepBankPUB-08156913
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged ovariectomized rats, salmon calcitonin protected against ovariectomy-induced loss of whole body bone mass.

    In plain wordsIn aged ovariectomized rats, calcitonin reduced whole body bone loss compared with untreated ovariectomized rats.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseWhole body bone mass loss
    Study

    ratn: not reported in source

    Aged osteopenic ovariectomized Wistar rats
    Comparator
    Ovariectomized rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    The results revealed a protective effect of both estrogen and calcitonin on ovariectomy-induced loss of whole body bone mass, but only estrogen had a significant effect on spinal BMC.
    2 context sentences
    Summary · context
    Seventy-nine 1-yr-old retired breeder Wistar rats were randomized into seven groups: 1) sham-operated, 2) OVX, 3) OVX plus estrogen, 4) OVX plus salmon calcitonin, 5) OVX plus human (h) PTH-(1-38), 6) OVX plus hPTH-(1-38) and estrogen, and finally, 7) OVX plus hPTH-(1-38) and calcitonin.
    Summary · context
    Treatment regimens were initiated 8 weeks after ovariectomy and continued for 24 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged ovariectomized rats, calcitonin had no significant effect on spinal bone mineral content.

    In plain wordsIn aged ovariectomized rats, calcitonin did not significantly change spinal bone mineral content compared with untreated ovariectomized rats.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeSpinal bone mineral content
    Study

    ratn: not reported in source

    Aged osteopenic ovariectomized Wistar rats
    Comparator
    Ovariectomized rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    The results revealed a protective effect of both estrogen and calcitonin on ovariectomy-induced loss of whole body bone mass, but only estrogen had a significant effect on spinal BMC.
    2 context sentences
    Summary · context
    Seventy-nine 1-yr-old retired breeder Wistar rats were randomized into seven groups: 1) sham-operated, 2) OVX, 3) OVX plus estrogen, 4) OVX plus salmon calcitonin, 5) OVX plus human (h) PTH-(1-38), 6) OVX plus hPTH-(1-38) and estrogen, and finally, 7) OVX plus hPTH-(1-38) and calcitonin.
    Summary · context
    Treatment regimens were initiated 8 weeks after ovariectomy and continued for 24 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged ovariectomized rats, calcitonin did not restore bone mass to sham-operated levels.

    In plain wordsIn aged ovariectomized rats, bone mass with calcitonin remained below sham-operated levels.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseRestoration of bone mass
    Study

    ratn: not reported in source

    Aged osteopenic ovariectomized Wistar rats
    Comparator
    Sham-operated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both estrogen and calcitonin reduce the ovariectomy-induced bone loss, but cannot restore bone mass to sham-operated levels.
    2 context sentences
    Summary · context
    Seventy-nine 1-yr-old retired breeder Wistar rats were randomized into seven groups: 1) sham-operated, 2) OVX, 3) OVX plus estrogen, 4) OVX plus salmon calcitonin, 5) OVX plus human (h) PTH-(1-38), 6) OVX plus hPTH-(1-38) and estrogen, and finally, 7) OVX plus hPTH-(1-38) and calcitonin.
    Summary · context
    Treatment regimens were initiated 8 weeks after ovariectomy and continued for 24 weeks.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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