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Study · Randomized controlled trial · n = 24 · 1994

6 results

Comparison between nafarelin and leuprolide acetate for in vitro fertilization: preliminary clinical study.

Dantas ZN, Vicino M, Balmaceda JP, Asch RH, Stone SC

Fertility and sterility1 Apr 1994Cited by 5 (Europe PMC)

PMID8150114 (opens in a new tab)DOI10.1016/s0015-0282(16)56649-7 (opens in a new tab)PepBankPUB-08150114
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women undergoing IVF, day 2 FSH did not differ statistically between nafarelin and leuprolide.

    In plain wordsIn women undergoing IVF, day 2 FSH did not differ statistically between nafarelin and leuprolide.

    Peptide
    Nafarelin
    Outcome
    No significant changeDay 2 FSH
    Study

    n = 24

    Comparator
    Leuprolide acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 micrograms twice daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    Hormone profiles on cycle day 2 showed no statistical difference between both GnRH-a groups in FSH levels and a slight statistical difference for E2 levels.
    2 context sentences
    Summary · context
    Twenty-four women were assigned randomly to either nafarelin acetate or LA during IVF cycles.
    Summary · context
    Intranasal nafarelin at a dosage of 200 micrograms twice daily or LA at a dose of 1 mg/d SC was administered.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women undergoing IVF, day 2 estradiol showed a slight statistical difference between nafarelin and leuprolide, with direction unreported.

    In plain wordsIn women undergoing IVF, day 2 estradiol differed between nafarelin and leuprolide, but the abstract does not state which was higher.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedDay 2 estradiol
    Study

    n = 24

    Comparator
    Leuprolide acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 micrograms twice daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    Hormone profiles on cycle day 2 showed no statistical difference between both GnRH-a groups in FSH levels and a slight statistical difference for E2 levels.
    2 context sentences
    Summary · context
    Twenty-four women were assigned randomly to either nafarelin acetate or LA during IVF cycles.
    Summary · context
    Intranasal nafarelin at a dosage of 200 micrograms twice daily or LA at a dose of 1 mg/d SC was administered.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women undergoing IVF, estradiol, FSH and LH on day 8 and the hCG injection day did not differ significantly between nafarelin and leuprolide.

    In plain wordsIn women undergoing IVF, follicular estradiol, FSH and LH did not differ significantly between nafarelin and leuprolide.

    Peptide
    Nafarelin
    Outcome
    No significant changeFollicular estradiol, FSH and LH
    Study

    n = 24

    Comparator
    Leuprolide acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 micrograms twice daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    Patient response as demonstrated by follicular phase of E2, FSH, and LH measured on cycle day 8 and the day of hCG injection showed no statistically significant difference in both groups.
    2 context sentences
    Summary · context
    Twenty-four women were assigned randomly to either nafarelin acetate or LA during IVF cycles.
    Summary · context
    Intranasal nafarelin at a dosage of 200 micrograms twice daily or LA at a dose of 1 mg/d SC was administered.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women undergoing IVF, follicle counts, eggs retrieved, egg quality, fertilization, and transferred and frozen embryos were similar with nafarelin and leuprolide.

    In plain wordsIn women undergoing IVF, follicle, egg, fertilization, and embryo outcomes were similar with nafarelin and leuprolide.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedFollicles, eggs, fertilization and embryo outcomes
    Study

    n = 24

    Comparator
    Leuprolide acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 micrograms twice daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    Furthermore, the mean number of follicles, eggs retrieved, egg quality, fertilization rate, and number of embryos transferred and frozen were similar.
    2 context sentences
    Summary · context
    Twenty-four women were assigned randomly to either nafarelin acetate or LA during IVF cycles.
    Summary · context
    Intranasal nafarelin at a dosage of 200 micrograms twice daily or LA at a dose of 1 mg/d SC was administered.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In women undergoing IVF, cycle cancellation did not differ statistically between nafarelin and leuprolide.

    In plain wordsIn women undergoing IVF, cycle cancellation did not differ statistically between nafarelin and leuprolide.

    Peptide
    Nafarelin
    Outcome
    No significant changeCycle cancellation
    Study

    n = 24

    Comparator
    Leuprolide acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 micrograms twice daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    The cycle cancellation rate and pregnancy rate per stimulation start were also not statistically different between the two groups.
    2 context sentences
    Summary · context
    Twenty-four women were assigned randomly to either nafarelin acetate or LA during IVF cycles.
    Summary · context
    Intranasal nafarelin at a dosage of 200 micrograms twice daily or LA at a dose of 1 mg/d SC was administered.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In women undergoing IVF, pregnancy per stimulation start did not differ statistically between nafarelin and leuprolide.

    In plain wordsIn women undergoing IVF, pregnancy per stimulation start did not differ statistically between nafarelin and leuprolide.

    Peptide
    Nafarelin
    Outcome
    No significant changePregnancy per stimulation start
    Study

    n = 24

    Comparator
    Leuprolide acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 micrograms twice daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    The cycle cancellation rate and pregnancy rate per stimulation start were also not statistically different between the two groups.
    2 context sentences
    Summary · context
    Twenty-four women were assigned randomly to either nafarelin acetate or LA during IVF cycles.
    Summary · context
    Intranasal nafarelin at a dosage of 200 micrograms twice daily or LA at a dose of 1 mg/d SC was administered.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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