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Study · Measured the body's own peptide · 1994

4 results

Structure of the alpha-inhibin gene and its regulation in the ruminant gonad: inverse relationship to oxytocin gene expression.

Ungefroren H, Wathes DC, Walther N, Ivell R

Biology of reproduction1 Feb 1994Cited by 7 (Europe PMC)

PMID8142557 (opens in a new tab)DOI10.1095/biolreprod50.2.401 (opens in a new tab)PepBankPUB-08142557
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ruminant ovary and testis, expression of the alpha-inhibin and oxytocin genes was inversely regulated.

    In plain wordsIn the ovary and testis of ruminants, the body's own oxytocin gene was active when the alpha-inhibin gene was less active.

    Peptide
    Oxytocin
    Outcome
    MixedInverse expression of alpha-inhibin and oxytocin genes in ruminant ovary and testis
    Study

    ruminantn: not reported in source

    ruminant ovary and testis (Northern hybridization)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The genes for the alpha subunit of inhibin and for the nonapeptide hormone oxytocin are both expressed in the granulosa cells of the ruminant follicle as well as in the Sertoli cells of the ruminant testis. Northern hybridization of mRNA from both ovary and testis indicate that in both gonads the ex…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In luteinizing granulosa cells, in vitro and in vivo, the oxytocin gene was up-regulated while the alpha-inhibin gene was down-regulated.

    In plain wordsIn ruminant ovary cells, the body's own oxytocin gene turned up as the alpha-inhibin gene turned down.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin gene up-regulation in luteinizing granulosa cells
    Study

    ruminantn: not reported in source

    luteinizing granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In the luteinizing granulosa cells, in vitro as in vivo, the alpha-inhibin gene is down-regulated when the oxytocin gene is up-regulated.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In bull and sheep Sertoli cells, the oxytocin gene was up-regulated in early puberty, together with down-regulation of the alpha-inhibin gene.

    In plain wordsIn bull and sheep testis, the body's own oxytocin gene turned up in early puberty while the alpha-inhibin gene turned down.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin gene up-regulation in Sertoli cells at early puberty
    Study

    bovine and ovinen: not reported in source

    Sertoli cells of bull and sheep testis
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In the Sertoli cells of the bull and sheep testis, the situation is similar, with the alpha-inhibin gene being up-regulated in the prepubertal gonad and down-regulated concomitantly with an up-regulation of the oxytocin gene in early puberty.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In ruminant gonadal cells, the oxytocin gene, like the alpha-inhibin gene, can be up-regulated by FSH or by forskolin.

    In plain wordsIn ruminant gonad cells, FSH or forskolin raised the body's own oxytocin gene activity.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin gene up-regulation by FSH or forskolin
    Study

    bovine and ovinen: not reported in source

    ruminant granulosa and Sertoli cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Comparison of the alpha-inhibin and oxytocin genes indicates that although both can be up-regulated by FSH or by forskolin within the same cells, different mechanisms of signal transduction are involved to explain the temporal differences in expression.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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