Sustained suppression of serum LH, FSH and testosterone and increase of high-density lipoprotein cholesterol by daily injections of the GnRH antagonist cetrorelix over 8 days in normal men.

Behre HM, Böckers A, Schlingheider A, Nieschlag E

Clinical endocrinology1 Feb 1994Cited by 25 (Europe PMC)

PMID8137524DOI10.1111/j.1365-2265.1994.tb02475.xPepBankPUB-08137524

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanNon-randomized trialSafety outcome
In normal men given daily cetrorelix, the only adverse side-effect besides symptoms of androgen deficiency was a mild painless local erythema at the injection site that disappeared within an hour.
In plain wordsIn normal men given daily cetrorelix, the only other side-effect seen was mild redness at the injection site that faded within an hour.
Peptide
Cetrorelix
Outcome
Not applicableOther adverse effects
Study
n = 16
Outcome group
Adverse events · Whole body
Studied dose
2, 5 and 10 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
Apart from those symptoms caused by androgen deficiency, the only adverse side-effect observed was a mild painless local erythema at the injection site that disappeared within an hour.
2 context sentences(design, population, supporting numbers)
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752411
02HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 2 mg significantly suppressed LH one day after the first injection, with subsequent fluctuations.
In plain wordsIn normal men, cetrorelix 2 mg reduced LH from baseline, with subsequent fluctuations.
Peptide
Cetrorelix
Outcome
DecreaseLH suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
One day after the first cetrorelix injection, serum LH and testosterone concentrations were significantly suppressed in all treatment groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Whereas in the 2 and 5-mg dose groups LH and testosterone showed some fluctuations, daily injections of 10 mg cetrorelix consistently suppressed LH and testosterone in all men.
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752401
03HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 2 mg significantly suppressed testosterone one day after the first injection, with subsequent fluctuations.
In plain wordsIn normal men, cetrorelix 2 mg reduced testosterone from baseline, with subsequent fluctuations.
Peptide
Cetrorelix
Outcome
DecreaseTestosterone suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
One day after the first cetrorelix injection, serum LH and testosterone concentrations were significantly suppressed in all treatment groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Whereas in the 2 and 5-mg dose groups LH and testosterone showed some fluctuations, daily injections of 10 mg cetrorelix consistently suppressed LH and testosterone in all men.
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752402
04HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 5 mg significantly suppressed LH one day after the first injection, with subsequent fluctuations.
In plain wordsIn normal men, cetrorelix 5 mg reduced LH from baseline, with subsequent fluctuations.
Peptide
Cetrorelix
Outcome
DecreaseLH suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
One day after the first cetrorelix injection, serum LH and testosterone concentrations were significantly suppressed in all treatment groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Whereas in the 2 and 5-mg dose groups LH and testosterone showed some fluctuations, daily injections of 10 mg cetrorelix consistently suppressed LH and testosterone in all men.
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752403
05HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 5 mg significantly suppressed testosterone one day after the first injection, with subsequent fluctuations.
In plain wordsIn normal men, cetrorelix 5 mg reduced testosterone from baseline, with subsequent fluctuations.
Peptide
Cetrorelix
Outcome
DecreaseTestosterone suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
One day after the first cetrorelix injection, serum LH and testosterone concentrations were significantly suppressed in all treatment groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Whereas in the 2 and 5-mg dose groups LH and testosterone showed some fluctuations, daily injections of 10 mg cetrorelix consistently suppressed LH and testosterone in all men.
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752404
06HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 10 mg significantly suppressed LH after the first injection and consistently suppressed it in all men.
In plain wordsIn normal men, cetrorelix 10 mg consistently reduced LH from baseline.
Peptide
Cetrorelix
Outcome
DecreaseLH suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
One day after the first cetrorelix injection, serum LH and testosterone concentrations were significantly suppressed in all treatment groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Whereas in the 2 and 5-mg dose groups LH and testosterone showed some fluctuations, daily injections of 10 mg cetrorelix consistently suppressed LH and testosterone in all men.
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752405
07HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 10 mg significantly suppressed testosterone after the first injection and consistently suppressed it in all men.
In plain wordsIn normal men, cetrorelix 10 mg consistently reduced testosterone from baseline.
Peptide
Cetrorelix
Outcome
DecreaseTestosterone suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
One day after the first cetrorelix injection, serum LH and testosterone concentrations were significantly suppressed in all treatment groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Whereas in the 2 and 5-mg dose groups LH and testosterone showed some fluctuations, daily injections of 10 mg cetrorelix consistently suppressed LH and testosterone in all men.
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752406
08HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 10 mg suppressed FSH below normal from day 1 through 5 days after the last injection.
In plain wordsIn normal men, cetrorelix 10 mg reduced FSH below normal through 5 days after the last injection.
Peptide
Cetrorelix
Outcome
DecreaseFSH suppression
Study
n = 4
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 mg daily · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
In addition, in this group serum FSH concentrations were significantly suppressed to subnormal values 1 day after the first injection and remained in this range up to 5 days after the last injection.
2 context sentences(design, population, supporting numbers)
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752407
09HumanNon-randomized trialEfficacy outcome
In normal men, cetrorelix 10 mg produced a maximal HDL cholesterol increase of 0.38 +/- 0.13 mmol/l (14.8 +/- 5.1 mg/dl).
In plain wordsIn normal men, cetrorelix 10 mg increased HDL cholesterol from baseline by up to 0.38 +/- 0.13 mmol/l.
Peptide
Cetrorelix
Outcome
IncreaseHDL cholesterol
Study
n = 4
Outcome group
Lipids · Metabolic and weight
Studied dose
10 mg daily · subcutaneous · 8 daysAs given in this study (human).
Measurements
maximal HDL cholesterol increase
0.38 mmol/l
10 mg group, mean
maximal HDL cholesterol increase SEM
0.13 mmol/l
10 mg group, SEM
maximal HDL cholesterol increase
14.8 mg/dl
10 mg group, mean
maximal HDL cholesterol increase SEM
5.1 mg/dl
10 mg group, SEM
Source sentences
Summary
A time and dose-dependent increase of high-density lipoprotein cholesterol was observed during cetrorelix-induced testosterone deprivation with a maximal increase of 0.38 +/- 0.13 mmol/l (14.8 +/- 5.1 mg/dl; mean +/- SEM) in the 10-mg dose group.
2 context sentences(design, population, supporting numbers)
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752408
10HumanNon-randomized trialSafety outcome
In normal men, libido significantly decreased during cetrorelix-induced testosterone suppression.
In plain wordsIn normal men, libido decreased from baseline during cetrorelix treatment.
Peptide
Cetrorelix
Outcome
DecreaseLibido
Study
n: not reported in source
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
In addition, parallel to suppressed testosterone the volunteers' libido was significantly reduced under the GnRH antagonist.
2 context sentences(design, population, supporting numbers)
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752409
11HumanNon-randomized trialSafety outcome
In normal men, mild painless injection-site erythema that disappeared within an hour was observed during daily cetrorelix injections.
In plain wordsIn normal men, mild painless injection-site redness disappeared within an hour after cetrorelix.
Peptide
Cetrorelix
Outcome
Not applicableInjection-site erythema
Study
n: not reported in source
Outcome group
Adverse events · Skin and wound
Studied dose
Dose not stated · subcutaneous · 8 daysAs given in this study (human).
Source sentences
Summary
Apart from those symptoms caused by androgen deficiency, the only adverse side-effect observed was a mild painless local erythema at the injection site that disappeared within an hour.
2 context sentences(design, population, supporting numbers)
Summary · context
Following two control examinations 16 young men were randomly assigned to four study groups (n = 4/group).
Summary · context
Daily doses of 0 (placebo), 2, 5, and 10 mg cetrorelix were injected subcutaneously at 0800 h for 8 days and morning and evening blood samples were obtained for 3 weeks.
Report a problemFND-0813752410

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Version history

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Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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Sustained suppression of serum LH, FSH and testosterone and increase of high-density lipoprotein cholesterol by daily injections of the GnRH antagonist cetrorelix over 8 days in normal men.

Summary

Results from this study11

Version history

Subjects

Publication types

MeSH terms