Insulin-like growth factors enhance phagocytosis by human neutrophils in vitro.

Jin GF, Guo YS, Ball C, Houston CW

Regulatory peptides1 Dec 1993Cited by 11 (Europe PMC)

PMID8134615DOI10.1016/0167-0115(93)90434-aPepBankPUB-08134615

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In human neutrophils, des(1‑3)-IGF-I significantly increased the chemiluminescence response.
In plain wordsIn lab tests, des(1‑3)-IGF-I increased the response of human neutrophils.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseChemiluminescence response
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Studied dose
6.5 nM · 20 minAs given in this study (human).
Source sentences
Summary
The administration of 6.5 nM of insulin-like growth factor I (IGF-I), des(1-3)-IGF-I, IGF-II or insulin to PMNs for 20 min resulted in significant increases of the CL response for all test preparations.
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
Report a problemFND-0813461501
02LabIn vitro (cells)Activity measurement
In human neutrophils, des(1‑3)-IGF-I was the most potent chemiluminescence stimulator among the tested preparations.
In plain wordsIn lab tests, des(1‑3)-IGF-I stimulated neutrophils more potently than IGF-I, IGF-II or insulin.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseChemiluminescence stimulation potency
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Comparator
IGF-I, IGF-II and insulin
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Des(1-3)-IGF-I, a truncated IGF-I with low affinity binding to IGF binding proteins (IGFBPs), was the most potent CL stimulator.
2 context sentences(design, population, supporting numbers)
Summary · context
The administration of 6.5 nM of insulin-like growth factor I (IGF-I), des(1-3)-IGF-I, IGF-II or insulin to PMNs for 20 min resulted in significant increases of the CL response for all test preparations.
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
Report a problemFND-0813461502

Studies that did not test the peptide alone6

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In human neutrophils, EGTA at 0.25 nM significantly inhibited des(1‑3)-IGF-I-evoked chemiluminescence.
In plain wordsIn lab tests, EGTA reduced the neutrophil response evoked by des(1‑3)-IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseEGTA inhibition of evoked chemiluminescence at 0.25 nM
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0813461503
04LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In human neutrophils, EGTA at 1.0 nM significantly inhibited des(1‑3)-IGF-I-evoked chemiluminescence.
In plain wordsIn lab tests, EGTA reduced the neutrophil response evoked by des(1‑3)-IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseEGTA inhibition of evoked chemiluminescence at 1.0 nM
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0813461504
05LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In human neutrophils, nifedipine significantly inhibited des(1‑3)-IGF-I-evoked chemiluminescence.
In plain wordsIn lab tests, nifedipine reduced the neutrophil response evoked by des(1‑3)-IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseNifedipine inhibition of evoked chemiluminescence
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0813461505
06LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In human neutrophils, pertussis toxin at 0.05 micrograms/ml significantly inhibited des(1‑3)-IGF-I-evoked chemiluminescence.
In plain wordsIn lab tests, pertussis toxin reduced the neutrophil response evoked by des(1‑3)-IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreasePertussis toxin inhibition at 0.05 micrograms/ml
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0813461506
07LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In human neutrophils, pertussis toxin at 1.0 micrograms/ml significantly inhibited des(1‑3)-IGF-I-evoked chemiluminescence.
In plain wordsIn lab tests, pertussis toxin reduced the neutrophil response evoked by des(1‑3)-IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreasePertussis toxin inhibition at 1.0 micrograms/ml
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0813461507
08LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In human neutrophils, cholera toxin significantly inhibited des(1‑3)-IGF-I-evoked chemiluminescence.
In plain wordsIn lab tests, cholera toxin reduced the neutrophil response evoked by des(1‑3)-IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseCholera toxin inhibition of evoked chemiluminescence
Study
humann: not reported in source
Blood polymorphonuclear neutrophils
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).
1 context sentence(design, population, supporting numbers)
Summary · context
Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0813461508

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:52 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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