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Study · Animal study (in vivo) · sheep · 1993

8 results

Direct infusion of a variant of insulin-like growth factor-I into the skin of sheep and effects on local blood flow, amino acid utilization and cell replication.

Harris PM, McBride BW, Gurnsey MP, Sinclair BR, Lee J

The Journal of endocrinology1 Dec 1993Cited by 12 (Europe PMC)

PMID8133213 (opens in a new tab)DOI10.1677/joe.0.1390463 (opens in a new tab)PepBankPUB-08133213
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, local infusion of long-R3-IGF-I into the skin increased skin blood flow.

    In plain wordsIn sheep, long-R3-IGF-I infused into the skin increased blood flow to the skin.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin blood flow
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Vascular function · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I caused a significant increase in the skin blood flow (P < 0.05), utilization of oxygen (P < 0.05), uptake of cysteine (P < 0.05) and phenylalanine (P < 0.001), and the rate of utilization of cysteine (P < 0.05) for protein synthesis.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, local infusion of long-R3-IGF-I into the skin increased oxygen utilization.

    In plain wordsIn sheep, long-R3-IGF-I infused into the skin increased oxygen use by the skin.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin oxygen utilization
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I caused a significant increase in the skin blood flow (P < 0.05), utilization of oxygen (P < 0.05), uptake of cysteine (P < 0.05) and phenylalanine (P < 0.001), and the rate of utilization of cysteine (P < 0.05) for protein synthesis.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, local infusion of long-R3-IGF-I into the skin increased cysteine uptake.

    In plain wordsIn sheep, long-R3-IGF-I infused into the skin increased cysteine uptake by the skin.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin cysteine uptake
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I caused a significant increase in the skin blood flow (P < 0.05), utilization of oxygen (P < 0.05), uptake of cysteine (P < 0.05) and phenylalanine (P < 0.001), and the rate of utilization of cysteine (P < 0.05) for protein synthesis.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, local infusion of long-R3-IGF-I into the skin increased phenylalanine uptake.

    In plain wordsIn sheep, long-R3-IGF-I infused into the skin increased phenylalanine uptake by the skin.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin phenylalanine uptake
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I caused a significant increase in the skin blood flow (P < 0.05), utilization of oxygen (P < 0.05), uptake of cysteine (P < 0.05) and phenylalanine (P < 0.001), and the rate of utilization of cysteine (P < 0.05) for protein synthesis.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, local infusion of long-R3-IGF-I into the skin increased the rate of cysteine utilization for protein synthesis.

    In plain wordsIn sheep, long-R3-IGF-I infused into the skin increased how much cysteine the skin used to make protein.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseCysteine utilization for protein synthesis
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I caused a significant increase in the skin blood flow (P < 0.05), utilization of oxygen (P < 0.05), uptake of cysteine (P < 0.05) and phenylalanine (P < 0.001), and the rate of utilization of cysteine (P < 0.05) for protein synthesis.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, long-R3-IGF-I increased skin amino acid uptake whether the skin was in negative or positive amino acid balance before infusion.

    In plain wordsIn sheep, long-R3-IGF-I increased amino acid uptake in the skin whatever the skin's balance was before infusion.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseAmino acid uptake regardless of prior amino acid balance
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I increased amino acid uptake regardless of whether the skin was in negative or positive amino acid balance prior to infusion.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, skin amino acid utilization returned towards pre-infusion levels during the recovery period after the infusion stopped.

    In plain wordsIn sheep, the skin's amino acid use went back toward its earlier level after the infusion stopped.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseAmino acid utilization after infusion stopped
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Pre-infusion baseline
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    During the recovery period amino acid utilization by skin returned towards preinfusion levels.
    2 context sentences
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, local infusion of long-R3-IGF-I had no effect on the number of replicating cells in wool follicle bulbs.

    In plain wordsIn sheep, long-R3-IGF-I infused into the skin did not change the number of dividing cells in wool follicles.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeReplicating cell numbers in wool follicle bulbs
    Study

    sheepn = 6

    Conscious sheep, local infusion into skin artery of abdominal flank
    Comparator
    Contralateral skin
    Outcome group
    Cell proliferation and differentiation · Skin and wound
    Studied dose
    Dose not stated · local infusion into skin artery · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    No effects of IGF-I were found on replicating cell numbers in the bulbs of wool follicles.
    3 context sentences
    Summary · context
    Numbers of cells replicating in the bulbs of wool follicles in the IGF-I-infused area and in the skin on the contralateral side of each animal were measured after labelling with 5-bromo-2'-deoxyuridine.
    Summary · context
    In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum.
    Summary · context
    Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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