Human parathyroid hormone(1-34) increases bone formation and strength of cortical bone in aged rats.

Ejersted C, Andreassen TT, Nilsson MH, Oxlund H

European journal of endocrinology1 Feb 1994Cited by 46 (Europe PMC)

PMID8130897DOI10.1530/eje.0.1300201PepBankPUB-08130897

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) did not affect body weight versus vehicle.
In plain wordsIn rats, PTH did not affect body weight versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeBody weight
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Body weight · Metabolic and weight
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
The PTH(1-34) treatment did not affect the body weights or the lengths of the femora.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089701
02AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) did not affect femoral length versus vehicle.
In plain wordsIn rats, PTH did not affect thigh bone length versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeFemoral length
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
The PTH(1-34) treatment did not affect the body weights or the lengths of the femora.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089702
03AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) produced new bone formation that filled intracortical cavities compared with vehicle.
In plain wordsIn rats, PTH produced new bone that filled cavities inside cortical bone compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseIntracortical cavity filling
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
After PTH treatment, double labelling and new bone formation filling in these cavities were found.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089703
04AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased periosteal bone formation rate versus vehicle.
In plain wordsIn rats, PTH increased bone formation at the outer surface versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePeriosteal bone formation rate
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, an increased bone formation rate was observed both at the periosteum and at the endosteum.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089704
05AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased endosteal bone formation rate versus vehicle.
In plain wordsIn rats, PTH increased bone formation at the inner surface versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseEndosteal bone formation rate
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, an increased bone formation rate was observed both at the periosteum and at the endosteum.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089705
06AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased bone cross-sectional area versus vehicle.
In plain wordsIn rats, PTH increased bone cross-sectional area versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCross-sectional area
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
This resulted in an increase in the cross-sectional area and a decrease in the medullary area.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089706
07AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) decreased medullary area versus vehicle.
In plain wordsIn rats, PTH decreased the marrow cavity area versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseMedullary area
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
This resulted in an increase in the cross-sectional area and a decrease in the medullary area.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089707
08AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased ultimate load versus vehicle.
In plain wordsIn rats, PTH increased the maximum load bone tolerated versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUltimate load
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
Three-point bending analysis revealed an increase in ultimate load, ultimate stiffness, energy absorption and ultimate stress after the PTH(1-34) treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089708
09AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased ultimate stiffness versus vehicle.
In plain wordsIn rats, PTH increased bone stiffness versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUltimate stiffness
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
Three-point bending analysis revealed an increase in ultimate load, ultimate stiffness, energy absorption and ultimate stress after the PTH(1-34) treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089709
10AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased bone energy absorption versus vehicle.
In plain wordsIn rats, PTH increased bone energy absorption versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseEnergy absorption
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
Three-point bending analysis revealed an increase in ultimate load, ultimate stiffness, energy absorption and ultimate stress after the PTH(1-34) treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089710
11AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) increased ultimate stress versus vehicle.
In plain wordsIn rats, PTH increased the maximum stress bone tolerated versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUltimate stress
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
Three-point bending analysis revealed an increase in ultimate load, ultimate stiffness, energy absorption and ultimate stress after the PTH(1-34) treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089711
12AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) did not change hydroxyproline concentration versus vehicle.
In plain wordsIn rats, PTH did not change bone hydroxyproline concentration versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeHydroxyproline concentration
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
No differences were found between the groups regarding the hydroxyproline concentration or apparent and real densities.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089712
13AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) did not change apparent bone density versus vehicle.
In plain wordsIn rats, PTH did not change apparent bone density versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeApparent density
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
No differences were found between the groups regarding the hydroxyproline concentration or apparent and real densities.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089713
14AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) did not change real bone density versus vehicle.
In plain wordsIn rats, PTH did not change real bone density versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeReal density
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
No differences were found between the groups regarding the hydroxyproline concentration or apparent and real densities.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089714
15AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, PTH(1-34) slightly reduced bone ash concentration versus vehicle.
In plain wordsIn rats, PTH slightly reduced bone ash concentration versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseAsh concentration
Study
ratn: not reported in source
Aged male rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 nmol/kg daily · injection · 56 daysAs given in this study (rat).
Source sentences
Summary
The ash concentration was, however, slightly reduced after PTH(1-34) treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of parathyroid hormone (PTH(1-34)) on mid-diaphyseal femoral cortical bone was studied in 2-year-old male rats.
Summary · context
The rats were treated with daily injections of 15 nmol/kg PTH(1-34) or vehicle for 56 days, and labelled with tetracycline and calcein on day 15 and day 40, respectively.
Report a problemFND-0813089715

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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