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Study · Animal study (in vivo) · 1993

3 results

[The replacement of accessory T-lymphocytes by synthetic peptides during the formation of splenic hematopoietic colonies].

Semina OV, Semenets TN, Deĭgin VI, Korotkov AM, Poverennyĭ AM

Biulleten' eksperimental'noi biologii i meditsiny1 Sept 1993Cited by 2 (Europe PMC)

PMID8118007 (opens in a new tab)PepBankPUB-08118007
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In the splenic colony model, thymogen did not show the colony formation increase reported for thymohexin after RAMBS treatment.

    In plain wordsIn animals, thymogen did not show the increase in spleen colony formation that thymohexin showed after bone marrow treatment.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeSplenic colony formation after RAMBS treatment
    Study

    n: not reported in source

    splenic hematopoietic colony formation
    Comparator
    Thymohexin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The former preparation failed to show the same action.
    2 context sentences
    Summary · context
    The latter immunomodulator was found to show a 3-fold increase in splenic colony formation after incubation of bone marrow cells with rabbit antimouse brain serum (RAMBS).
    Summary · context
    Whether accessory T cells can be replaced by the synthetic immunomodulators thymogen (Glu-Trp) and thymohexin (Arg-Lys-Asp-Val-Tyr-Arg) was studied.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In the splenic colony model, thymogen had an effect close to that of thymocytes.

    In plain wordsIn animals, thymogen had an effect on spleen colony formation close to that of thymocytes.

    Peptide
    Thymogen (oglufanide)
    Outcome
    Direction not reportedSplenic colony formation relative to thymocytes
    Study

    n: not reported in source

    splenic hematopoietic colony formation
    Comparator
    Thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Its effect was close to that of thymocytes.
    2 context sentences
    Summary · context
    The former preparation failed to show the same action.
    Summary · context
    Whether accessory T cells can be replaced by the synthetic immunomodulators thymogen (Glu-Trp) and thymohexin (Arg-Lys-Asp-Val-Tyr-Arg) was studied.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In irradiated recipients of RAMBS-treated bone marrow, thymogen did not suppress thymocyte stimulation of colony formation.

    In plain wordsIn irradiated animals receiving treated bone marrow, thymogen did not suppress thymocyte stimulation of colony formation.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeThymocyte stimulation of colony formation
    Study

    n: not reported in source

    splenic hematopoietic colony formation
    Comparator
    Thymocytes without thymogen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymogen did not suppress the stimulating activity of thymocytes.
    2 context sentences
    Summary · context
    When the recipients exposed to lethal irradiation were administered the RAMBS-treated bone marrow cells and one of the peptides, it was shown that in concomitant administration, thymohexin and thymocytes lost their ability to restore colony formation by RAMBS-treated bone marrow.
    Summary · context
    Whether accessory T cells can be replaced by the synthetic immunomodulators thymogen (Glu-Trp) and thymohexin (Arg-Lys-Asp-Val-Tyr-Arg) was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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