Basic fibroblast growth factor selectively amplifies the functional state of neurons producing neuropeptide Y but not somatostatin in cultures of fetal brain cells: evidence for a cooperative interaction with insulin-like growth factor-I.

Barnea A, Cho G

Endocrinology1 Oct 1993Cited by 14 (Europe PMC)

PMID8104779DOI10.1210/endo.133.4.8104779PepBankPUB-08104779

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In fetal rat brain cell cultures, adding long R3-IGF-I to bFGF raised NPY production after forskolin and PMA further than bFGF alone.
In plain wordsIn rat brain cell cultures, adding long R3-IGF-I to bFGF increased NPY production more than bFGF alone.
Peptide
IGF-1 LR3
Outcome
IncreaseNPY production with bFGF plus l-IGF-I versus bFGF alone
Study
ratn: not reported in source
Aggregate cultures of fetal rat cortex (17-day-old)
Comparator
bFGF alone
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
1 nMAs given in this study (rat).
Source sentences
Summary
NPY production in response to For + PMA was even greater than with bFGF alone (2-fold; p < 0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
The role of basic fibroblast growth factor (bFGF) in regulating the functional state of neuropeptide Y (NPY) neurons in the brain was investigated, using aggregate cultures, derived from 17-day-old fetal rat cortex maintained for 16 days in serum-free medium, as a model.
Report a problemFND-0810477901
02LabIn vitro (cells)Mechanism
In fetal rat brain cell cultures, long R3-IGF-I by itself did not raise NPY production.
In plain wordsIn rat brain cell cultures, long R3-IGF-I alone did not raise NPY production.
Peptide
IGF-1 LR3
Outcome
No significant changeNPY production with l-IGF-I alone
Study
ratn: not reported in source
Aggregate cultures of fetal rat cortex (17-day-old)
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
1 nMAs given in this study (rat).
Source sentences
Summary
even though l-IGF-I by itself was ineffective
1 context sentence(design, population, supporting numbers)
Summary · context
The role of basic fibroblast growth factor (bFGF) in regulating the functional state of neuropeptide Y (NPY) neurons in the brain was investigated, using aggregate cultures, derived from 17-day-old fetal rat cortex maintained for 16 days in serum-free medium, as a model.
Report a problemFND-0810477902
03LabIn vitro (cells)Mechanism
In fetal rat brain cell cultures, long R3-IGF-I did not amplify SRIF production after forskolin and PMA.
In plain wordsIn rat brain cell cultures, long R3-IGF-I did not increase somatostatin production.
Peptide
IGF-1 LR3
Outcome
No significant changeSomatostatin (SRIF) production with l-IGF-I alone
Study
ratn: not reported in source
Aggregate cultures of fetal rat cortex (17-day-old)
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
1 nMAs given in this study (rat).
Source sentences
Summary
To assess the selectivity of this process, we evaluated SRIF production in response to For + PMA and found that it was not amplified by bFGF, l-IGF-I, or bFGF + l-IGF-I.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of basic fibroblast growth factor (bFGF) in regulating the functional state of neuropeptide Y (NPY) neurons in the brain was investigated, using aggregate cultures, derived from 17-day-old fetal rat cortex maintained for 16 days in serum-free medium, as a model.
Report a problemFND-0810477903

Studies that did not test the peptide alone1

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

04LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism
In fetal rat brain cell cultures, the combination of bFGF and long R3-IGF-I did not amplify SRIF production after forskolin and PMA.
In plain wordsIn rat brain cell cultures, bFGF plus long R3-IGF-I together did not increase somatostatin production.
Peptide
IGF-1 LR3
Outcome
No significant changeSomatostatin (SRIF) production with bFGF plus l-IGF-I
Study
ratn: not reported in source
Aggregate cultures of fetal rat cortex (17-day-old)
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Source sentences
Summary
To assess the selectivity of this process, we evaluated SRIF production in response to For + PMA and found that it was not amplified by bFGF, l-IGF-I, or bFGF + l-IGF-I.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of basic fibroblast growth factor (bFGF) in regulating the functional state of neuropeptide Y (NPY) neurons in the brain was investigated, using aggregate cultures, derived from 17-day-old fetal rat cortex maintained for 16 days in serum-free medium, as a model.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0810477904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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