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Study · Randomized controlled trial · n = 100 · 1993

6 results

Octreotide infusion or emergency sclerotherapy for variceal haemorrhage.

Sung JJ, Chung SC, Lai CW, Chan FK, Leung JW, Yung MY, Kassianides C, Li AK

Lancet (London, England)1 Sept 1993Cited by 116 (Europe PMC)

PMID8103145 (opens in a new tab)DOI10.1016/0140-6736(93)91758-e (opens in a new tab)PepBankPUB-08103145
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In acute variceal hemorrhage, initial bleeding control was 84% with octreotide versus 90% with sclerotherapy (95% confidence interval 0-19.5, p = 0.55).

    In plain wordsIn acute variceal bleeding, octreotide controlled bleeding in 84% versus 90% with sclerotherapy, without a significant difference.

    Peptide
    Octreotide
    Outcome
    No significant changeInitial bleeding control
    Study

    n = 100

    Comparator
    Emergency sclerotherapy
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    50 micrograms bolus plus 50 micrograms per h infusion · intravenous · 48 hAs given in this study (human).

    Measurements

    Initial bleeding control
    84%
    octreotide group
    Initial bleeding control
    90%
    emergency sclerotherapy group
    95% confidence interval for difference in bleeding control (p = 0.55)
    0 to 19.5 not stated
    octreotide versus sclerotherapy

    Source sentences

    Summary
    Bleeding was initially controlled in 90% of patients by emergency sclerotherapy and in 84% by octreotide infusion (95% confidence interval 0-19.5, p = 0.55).
    1 context sentence
    Summary · context
    To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotid…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In acute variceal hemorrhage, early rebleeding (within 48 h of randomisation) did not differ significantly between octreotide and sclerotherapy (reported as 16% vs 14%).

    In plain wordsIn acute variceal bleeding, early rebleeding did not differ significantly between octreotide and sclerotherapy (reported as 16% vs 14%).

    Peptide
    Octreotide
    Outcome
    No significant changeEarly rebleeding
    Study

    n = 100

    Comparator
    Emergency sclerotherapy
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    50 micrograms bolus plus 50 micrograms per h infusion · intravenous · 48 hAs given in this study (human).

    Measurements

    Early rebleeding
    16%
    first value of '16% vs 14%'; group not labeled in abstract
    Early rebleeding
    14%
    second value of '16% vs 14%'; group not labeled in abstract

    Source sentences

    Summary
    There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%).
    1 context sentence
    Summary · context
    To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotid…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In acute variceal hemorrhage, blood transfusion did not differ significantly between octreotide and sclerotherapy (reported as 3 units vs 3.5).

    In plain wordsIn acute variceal bleeding, blood transfusion did not differ significantly between octreotide and sclerotherapy (reported as 3 units vs 3.5).

    Peptide
    Octreotide
    Outcome
    No significant changeBlood transfusion
    Study

    n = 100

    Comparator
    Emergency sclerotherapy
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    50 micrograms bolus plus 50 micrograms per h infusion · intravenous · 48 hAs given in this study (human).

    Measurements

    Blood transfusion
    3 units
    first value of '3 units vs 3.5'; group not labeled in abstract
    Blood transfusion
    3.5 units
    second value of '3 units vs 3.5'; group not labeled in abstract

    Source sentences

    Summary
    There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%).
    1 context sentence
    Summary · context
    To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotid…
  4. 04HumanRandomized controlled trialEfficacy outcome

    In acute variceal hemorrhage, hospital stay did not differ significantly between octreotide and sclerotherapy (reported as 5 days vs 6 days).

    In plain wordsIn acute variceal bleeding, hospital stay did not differ significantly between octreotide and sclerotherapy (reported as 5 days vs 6 days).

    Peptide
    Octreotide
    Outcome
    No significant changeHospital stay
    Study

    n = 100

    Comparator
    Emergency sclerotherapy
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    50 micrograms bolus plus 50 micrograms per h infusion · intravenous · 48 hAs given in this study (human).

    Measurements

    Hospital stay
    5 days
    first value of '5 days vs 6 days'; group not labeled in abstract
    Hospital stay
    6 days
    second value of '5 days vs 6 days'; group not labeled in abstract

    Source sentences

    Summary
    There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%).
    1 context sentence
    Summary · context
    To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotid…
  5. 05HumanRandomized controlled trialSafety outcome

    In acute variceal hemorrhage, hospital mortality did not differ significantly between octreotide and sclerotherapy (reported as 27% vs 20%).

    In plain wordsIn acute variceal bleeding, hospital mortality did not differ significantly between octreotide and sclerotherapy (reported as 27% vs 20%).

    Peptide
    Octreotide
    Outcome
    No significant changeHospital mortality
    Study

    n = 100

    Comparator
    Emergency sclerotherapy
    Outcome group
    Mortality · Gastrointestinal
    Studied dose
    50 micrograms bolus plus 50 micrograms per h infusion · intravenous · 48 hAs given in this study (human).

    Measurements

    Hospital mortality
    27%
    first value of '27% vs 20%'; group not labeled in abstract
    Hospital mortality
    20%
    second value of '27% vs 20%'; group not labeled in abstract

    Source sentences

    Summary
    There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%).
    1 context sentence
    Summary · context
    To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotid…
  6. 06HumanNon-randomized trialSafety outcome

    In acute variceal hemorrhage, no notable side effects were associated with octreotide.

    In plain wordsIn acute variceal bleeding, no notable side effects were associated with octreotide.

    Peptide
    Octreotide
    Outcome
    Not applicableNotable side effects
    Study

    n: not reported in source

    Outcome group
    Adverse events · Gastrointestinal
    Studied dose
    50 micrograms bolus plus 50 micrograms per h infusion · intravenous · 48 hAs given in this study (human).

    Source sentences

    Summary
    No notable side-effects were associated with octreotide.
    1 context sentence
    Summary · context
    To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotid…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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