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Study · Animal study (in vivo) · sheep · 1994

5 results

Constitutive growth hormone secretion in sheep after hypothalamopituitary disconnection and the direct in vivo pituitary effect of growth hormone releasing peptide 6.

Fletcher TP, Thomas GB, Willoughby JO, Clarke IJ

Neuroendocrinology1 Jul 1994Cited by 27 (Europe PMC)

PMID8090285 (opens in a new tab)DOI10.1159/000126722 (opens in a new tab)PepBankPUB-08090285
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In hypothalamopituitary-disconnected sheep, GHRP‑6 response magnitude was similar in wethers and ewes.

    In plain wordsIn sheep with disconnected hypothalamic and pituitary connections, males and females had similar responses to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH response by sex
    Study

    sheepn = 6

    hypothalamopituitary-disconnected sheep
    Comparator
    wethers versus ewes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 micrograms/kgAs given in this study (sheep).

    Source sentences

    Summary
    In the first series, 3/5 wethers and 3/5 of the ewes responded to GHRP-6 challenge; the magnitude of the response was similar in both sexes.
    1 context sentence
    Summary · context
    Five wethers and 5 ewes were taken approximately 300 days after HPD and injected with vehicle or 10 micrograms/kg of the synthetic hexapeptide growth hormone-releasing peptide 6 (GHRP-6); GH responses were monitored.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In hypothalamopituitary-disconnected wethers, GHRP‑6 produced a significantly lower GH response than GRF.

    In plain wordsIn sheep with disconnected hypothalamic and pituitary connections, GHRP‑6 released less growth hormone than GRF.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response versus GRF after HPD
    Study

    sheepn = 6

    hypothalamopituitary-disconnected wethers
    Comparator
    GRF
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 micrograms/kgAs given in this study (sheep).

    Source sentences

    Summary
    In the second series, responses to GRF were lower (48%) (p < 0.03) in HPD wethers than in control wethers, and responses to GHRP-6 were much lower (p < 0.01) than those to GRF in both controls and HPD wethers.
    1 context sentence
    Summary · context
    In a second series of sheep, 4 wethers and 6 HPD wethers were given saline, 0.5 micrograms/kg of synthetic growth hormone-releasing factor (GRF) or 5 micrograms/kg GHRP-6 and were blood-sampled to measure the plasma GH response.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In hypothalamopituitary-disconnected sheep, 3/5 wethers responded to GHRP‑6.

    In plain wordsIn sheep with disconnected hypothalamic and pituitary connections, 3/5 castrated males responded to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response in HPD wethers
    Study

    sheepn = 5

    hypothalamopituitary-disconnected wethers
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 micrograms/kgAs given in this study (sheep).

    Source sentences

    Summary
    In the first series, 3/5 wethers and 3/5 of the ewes responded to GHRP-6 challenge; the magnitude of the response was similar in both sexes.
    1 context sentence
    Summary · context
    Five wethers and 5 ewes were taken approximately 300 days after HPD and injected with vehicle or 10 micrograms/kg of the synthetic hexapeptide growth hormone-releasing peptide 6 (GHRP-6); GH responses were monitored.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In hypothalamopituitary-disconnected sheep, 3/5 ewes responded to GHRP‑6.

    In plain wordsIn sheep with disconnected hypothalamic and pituitary connections, 3/5 females responded to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response in HPD ewes
    Study

    sheepn = 5

    hypothalamopituitary-disconnected ewes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 micrograms/kgAs given in this study (sheep).

    Source sentences

    Summary
    In the first series, 3/5 wethers and 3/5 of the ewes responded to GHRP-6 challenge; the magnitude of the response was similar in both sexes.
    1 context sentence
    Summary · context
    Five wethers and 5 ewes were taken approximately 300 days after HPD and injected with vehicle or 10 micrograms/kg of the synthetic hexapeptide growth hormone-releasing peptide 6 (GHRP-6); GH responses were monitored.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In control wethers, GHRP‑6 produced a significantly lower GH response than GRF.

    In plain wordsIn control sheep, GHRP‑6 released less growth hormone than GRF.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response versus GRF in controls
    Study

    sheepn = 4

    control wethers
    Comparator
    GRF
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 micrograms/kgAs given in this study (sheep).

    Source sentences

    Summary
    In the second series, responses to GRF were lower (48%) (p < 0.03) in HPD wethers than in control wethers, and responses to GHRP-6 were much lower (p < 0.01) than those to GRF in both controls and HPD wethers.
    1 context sentence
    Summary · context
    In a second series of sheep, 4 wethers and 6 HPD wethers were given saline, 0.5 micrograms/kg of synthetic growth hormone-releasing factor (GRF) or 5 micrograms/kg GHRP-6 and were blood-sampled to measure the plasma GH response.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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