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Study · Not a test of the peptide alone · 1994

4 results

Characterization and localization of oxytocin receptors in the rat testis.

Bathgate RA, Sernia C

The Journal of endocrinology1 May 1994Cited by 20 (Europe PMC)

PMID8046305 (opens in a new tab)DOI10.1677/joe.0.1410343 (opens in a new tab)PepBankPUB-08046305
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat membrane fractions, the radiolabelled oxytocin receptor antagonist bound with high affinity in testis, mammary tissue and uterus.

    In plain wordsIn lab tests on rat tissue, a labelled oxytocin receptor blocker bound tightly to testis, mammary and uterus membranes.

    Peptide
    Oxytocin
    Outcome
    Not applicableBinding affinity of OT receptor antagonist in testis, mammary and uterus membranes
    Study

    ratn: not reported in source

    membrane fractions of rat testis, mammary tissue and uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Measurements

    Ka
    13.8 litres/nmol
    rat testis
    Ka
    20.3 litres/nmol
    rat mammary tissue
    Ka
    27.8 litres/nmol
    rat uterus

    Source sentences

    Summary
    125I-labelled OTA bound with high affinity to membrane fractions of the rat testis (Ka = 13.8 +/- 1.25 litres/nmol), mammary tissue (Ka = 20.3 +/- 4.36 litres/nmol) and uterus (Ka = 27.8 +/- 0.74 litres/nmol).
    1 context sentence
    Summary · context
    In this study oxytocin (OT) receptors have been characterized and localized in the testis of the rat using the radioiodinated OT receptor antagonist 125I-labelled d(CH2)5 [Tyr(Me)2,Thr4,Tyr9-NH2]-vasotocin (OTA).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat testis, competition studies with oxytocin and vasopressin receptor agonists and antagonists confirmed that the binding was to oxytocin receptors.

    In plain wordsIn lab tests on rat testis, competition tests showed that the binding was to oxytocin receptors.

    Peptide
    Oxytocin
    Outcome
    Not applicableIdentity of testis binding sites as OT receptors
    Study

    ratn: not reported in source

    rat testis membranes
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Competition studies with various OT and AVP receptor agonists and antagonists confirmed that the binding was to OT receptors.
    1 context sentence
    Summary · context
    In this study oxytocin (OT) receptors have been characterized and localized in the testis of the rat using the radioiodinated OT receptor antagonist 125I-labelled d(CH2)5 [Tyr(Me)2,Thr4,Tyr9-NH2]-vasotocin (OTA).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat testis, the vasopressin receptor density was much higher than the oxytocin receptor density.

    In plain wordsIn lab tests on rat testis, oxytocin receptors were far less dense than vasopressin receptors.

    Peptide
    Oxytocin
    Outcome
    Not applicableOT receptor density versus AVP receptor density in testis
    Study

    ratn: not reported in source

    rat testis membranes
    Comparator
    AVP receptor density
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Measurements

    OT receptor density
    5.2 fmol/mg protein
    rat testis
    AVP receptor density
    109 fmol/mg protein
    rat testis

    Source sentences

    Summary
    The AVP receptor density in the testis was much higher than the OT receptor density (109 +/- 12.3 vs 5.2 +/- 0.79 (mean +/- S.E.M.) fmol/mg protein).
    1 context sentence
    Summary · context
    In this study oxytocin (OT) receptors have been characterized and localized in the testis of the rat using the radioiodinated OT receptor antagonist 125I-labelled d(CH2)5 [Tyr(Me)2,Thr4,Tyr9-NH2]-vasotocin (OTA).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat testis, oxytocin receptors were present in the interstitial spaces, consistent with binding to Leydig cells.

    In plain wordsIn lab tests on rat testis, oxytocin receptors were found in the spaces between tubules, in line with binding to Leydig cells.

    Peptide
    Oxytocin
    Outcome
    Not applicableLocalization of OT receptors in testis
    Study

    ratn: not reported in source

    rat testis sections (autoradiography)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Autoradiographical localization showed that both OT and AVP receptors were present in the interstitial spaces in the testis consistent with binding to Leydig cells.
    1 context sentence
    Summary · context
    In this study oxytocin (OT) receptors have been characterized and localized in the testis of the rat using the radioiodinated OT receptor antagonist 125I-labelled d(CH2)5 [Tyr(Me)2,Thr4,Tyr9-NH2]-vasotocin (OTA).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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