Growth hormone (GH) secretion in active acromegaly after the combined administration of GH-releasing hormone and GH-releasing peptide-6.

Popovic V, Damjanovic S, Micic D, Petakov M, Dieguez C, Casanueva FF

The Journal of clinical endocrinology and metabolism1 Aug 1994Cited by 16 (Europe PMC)

PMID8045963DOI10.1210/jcem.79.2.8045963PepBankPUB-08045963

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialActivity measurement
In normal subjects, GH secretion after GHRP‑6 was 1787 +/- 510 micrograms per L/120 min.
In plain wordsIn normal subjects, GHRP‑6 stimulated growth hormone secretion.
Peptide
GHRP-6
Outcome
Direction not reportedGH secretion in normal subjects
Study
n = 12
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Measurements
GH AUC
1787 micrograms per L/120 min
GHRP-6
Source sentences
Summary
In normal subjects, GH secretion was 686 +/- 227 after GHRH, 1787 +/- 510 after GHRP-6, and 4111 +/- 671 after GHRH plus GHRP-6;
2 context sentences(design, population, supporting numbers)
Summary · context
Eleven acromegalic patients and 12 normal subjects, age and sex matched as controls, underwent 3 tests each on separate occasions, being challenged with GHRH (100 micrograms, iv), GHRP-6 (90 micrograms, iv), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE; micrograms per L/120 min).
Report a problemFND-0804596301
02HumanNon-randomized trialActivity measurement
In acromegalic patients, GH secretion after GHRP‑6 was 2595 +/- 762 micrograms per L/120 min.
In plain wordsIn patients with acromegaly, GHRP‑6 stimulated growth hormone secretion.
Peptide
GHRP-6
Outcome
Direction not reportedGH secretion in acromegaly
Study
n = 11
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Measurements
GH AUC
2595 micrograms per L/120 min
GHRP-6
Source sentences
Summary
In acromegalic patients, the level of GH secreted after GHRH was 1468 +/- 499, that after GHRP-6 was 2595 +/- 762, and that after GHRH plus GHRP-6 was 4949 +/- 1043; this last value was not significantly different from the arithmetical addition of levels produced by both compounds administered separately.
2 context sentences(design, population, supporting numbers)
Summary · context
Eleven acromegalic patients and 12 normal subjects, age and sex matched as controls, underwent 3 tests each on separate occasions, being challenged with GHRH (100 micrograms, iv), GHRP-6 (90 micrograms, iv), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE; micrograms per L/120 min).
Report a problemFND-0804596303

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

03HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In normal subjects, combined GHRH and GHRP‑6 produced GH secretion significantly above the arithmetic sum of separate responses.
In plain wordsIn normal subjects, combined GHRH and GHRP‑6 released more growth hormone than the sum of separate responses.
Peptide
GHRP-6
Outcome
IncreaseCombined GH secretion in normal subjects
Study
n = 12
Comparator
arithmetic sum of separate compounds
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
4111 micrograms per L/120 min
Normal subjects after GHRH plus GHRP-6
GH AUC
686 micrograms per L/120 min
Normal subjects after GHRH alone
GH AUC
1787 micrograms per L/120 min
Normal subjects after GHRP-6 alone
Source sentences
Summary
In normal subjects, GH secretion was 686 +/- 227 after GHRH, 1787 +/- 510 after GHRP-6, and 4111 +/- 671 after GHRH plus GHRP-6; the level of GH secreted after GHRH plus GHRP-6 treatment was significantly (P < 0.05) higher than the arithmetic sum of GH levels after both compounds administered separately.
2 context sentences(design, population, supporting numbers)
Summary · context
Eleven acromegalic patients and 12 normal subjects, age and sex matched as controls, underwent 3 tests each on separate occasions, being challenged with GHRH (100 micrograms, iv), GHRP-6 (90 micrograms, iv), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE; micrograms per L/120 min).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0804596302
04HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In acromegalic patients, combined GHRH and GHRP‑6 did not significantly exceed the arithmetic sum of separate GH responses.
In plain wordsIn patients with acromegaly, combined GHRH and GHRP‑6 did not significantly exceed the sum of separate growth hormone responses.
Peptide
GHRP-6
Outcome
No significant changeCombined GH secretion in acromegaly
Study
n = 11
Comparator
arithmetic sum of separate compounds
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
4949 micrograms per L/120 min
Acromegalic patients after GHRH plus GHRP-6
GH AUC
1468 micrograms per L/120 min
Acromegalic patients after GHRH alone
GH AUC
2595 micrograms per L/120 min
Acromegalic patients after GHRP-6 alone
Source sentences
Summary
In acromegalic patients, the level of GH secreted after GHRH was 1468 +/- 499, that after GHRP-6 was 2595 +/- 762, and that after GHRH plus GHRP-6 was 4949 +/- 1043; this last value was not significantly different from the arithmetical addition of levels produced by both compounds administered separately.
2 context sentences(design, population, supporting numbers)
Summary · context
Eleven acromegalic patients and 12 normal subjects, age and sex matched as controls, underwent 3 tests each on separate occasions, being challenged with GHRH (100 micrograms, iv), GHRP-6 (90 micrograms, iv), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE; micrograms per L/120 min).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0804596304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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