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Study · Animal study (in vivo) · sheep · 1994

8 results

Concentrations of thymulin in unextracted serum from pigs, sheep and cattle as measured by ELISA.

Davis SL, Safieh-Garabedian B, Khosraviani M

Journal of immunoassay1 May 1994Cited by 3 (Europe PMC)

PMID8040352 (opens in a new tab)DOI10.1080/15321819408013947 (opens in a new tab)PepBankPUB-08040352
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In a sheep injected with thymulin, the blood clearance half-life was 10.3 +/- 0.6 min.

    In plain wordsIn a sheep, injected thymulin had a blood clearance half-life of 10.3 minutes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableBlood clearance half-life
    Study

    sheepn = 1

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · injectionAs given in this study (sheep).

    Measurements

    Half-life
    10.3 min
    10.3 +/- 0.6 min after thymulin injection

    Source sentences

    Summary
    Serum thymulin concentrations in a sheep injected with thymulin was cleared from blood with a half-life (t1/2) of 10.3 +/- 0.6 min.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In pigs, somatotropin treatment did not affect serum thymulin concentrations.

    In plain wordsIn pigs, somatotropin did not change natural thymulin levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeSerum thymulin after somatotropin
    Study

    pign: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Using this assay, it was found that somatotropin (ST) treatment had no effect on serum thymulin concentrations in either pigs or cows.

    This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In cows, somatotropin treatment did not affect serum thymulin concentrations.

    In plain wordsIn cows, somatotropin did not change natural thymulin levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeSerum thymulin after somatotropin
    Study

    cown: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Using this assay, it was found that somatotropin (ST) treatment had no effect on serum thymulin concentrations in either pigs or cows.

    This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.

  3. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In pigs, serum thymulin concentrations increased between birth and 6 months of age.

    In plain wordsIn pigs, natural thymulin levels increased from birth to 6 months.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAge-related serum thymulin
    Study

    pign: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Serum thymulin concentrations increased between birth and 6 mo old in pigs.

    This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 05LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In animal serum assays, thymulin ELISA showed intraassay and interassay variability.

    In plain wordsIn lab tests, the thymulin assay varied within and between assay runs.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableELISA variability
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    Intraassay CV
    13.3%
    12.6 pg/mL
    Intraassay CV
    6.4%
    50.5 pg/mL
    Interassay CV
    24.2%
    assay

    Source sentences

    Summary
    This assay was quite variable (intraassay C.V. of 13.3 and 6.4% at 12.6 and 50.5 pg/mL and interassay C.V. of 24.2%).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 06LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In pig, sheep and cow serum, dilution curves paralleled the thymulin standard without apparent nonspecific interference.

    In plain wordsIn lab tests, animal serum dilution curves matched the thymulin standard, suggesting no nonspecific interference.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeSerum assay interference
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    Serial dilutions of serum from these species produced inhibition curves parallel to the reference standard, suggesting that there were no substances in serum causing non-specific interference in the assay.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 07LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In the thymulin assay, other tested thymic peptides caused no problematic displacement of antiserum binding.

    In plain wordsIn lab tests, other thymic peptides did not cause problematic interference with thymulin binding.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeAssay cross-reactivity
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    In addition, none of the other thymic peptides tested resulted in problematic displacement of thymulin binding to the antiserum.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 08LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In sheep serum, thymulin activity separated into three chromatographic peaks with approximate molecular weights of 95, 80 and 1 kDa.

    In plain wordsIn lab tests, natural sheep thymulin activity appeared in three peaks.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableChromatographic activity peaks
    Study

    sheepn: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Measurements

    Molecular weight
    ≈ 95 kDa
    peak
    Molecular weight
    ≈ 80 kDa
    peak
    Molecular weight
    ≈ 1 kDa
    peak

    Source sentences

    Summary
    Chromatographic separation of thymulin activity in sheep serum showed three peaks with approximate MW estimates of 95, 80 and 1 kDa.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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