In severely burned children, Nutropin donor sites healed in 6.8 +/- 1.5 days versus 8.5 +/- 2.3 days with placebo (p < 0.01).
In plain wordsIn severely burned children, skin donor sites healed faster with Nutropin than with placebo.
- Peptide
- HGH (somatotropin)
- Outcome
- DecreaseDonor site healing time
- Study
n = 46
- Comparator
- Placebo
- Outcome group
- Wound healing · Skin and wound
- Studied dose
- 0.2 mg/kg/day · subcutaneous or intramuscular injectionAs given in this study (human).
Measurements
- Healing time
- 6.8 days
- Nutropin mean
- Healing time SD
- 1.5 days
- Nutropin
- Healing time
- 8.5 days
- placebo mean
- Healing time SD
- 2.3 days
- placebo
Source sentences
Donor sites in patients receiving Nutropin (n = 20) or Protropin (n = 18) healed at 6.8 +/- 1.5 and 6.0 +/- 1.5 (mean +/- SD) days, respectively, whereas those receiving placebo (n = 26) had a first donor site healing time of 8.5 +/- 2.3 days.
3 context sentences(design, population, supporting numbers)
Both groups receiving rhGH showed a significant reduction in donor site healing time compared with placebo at p < 0.01.
Forty-six children, with a > 40% total body surface area and > 20% total body surface area full-thickness burn were entered in a double-blind, randomized study to receive rhGH within 8 days of injury.
Twenty received (0.2 mg/kg/day) Nutropin or placebo by subcutaneous or intramuscular injection beginning on the morning of the initial excision.