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Study · Ex vivo tissue · rat · 1994

7 results

Induction of pituitary cell type differentiation by delta sleep-inducing peptide.

Héritier AG, Stettler O, Dubois PM

Neuroendocrinology1 May 1994Cited by 3 (Europe PMC)

PMID8022523 (opens in a new tab)DOI10.1159/000126694 (opens in a new tab)PepBankPUB-08022523
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP induced differentiation of LH cells in a dose-dependent manner.

    In plain wordsIn cultured rat pituitary tissue, DSIP made more LH-producing cells develop, and more so at higher doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLH cell differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    Addition of DSIP during the first day of culture induced differentiation of LH and TSH cells only. The effect was dose-dependent.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).
  2. 02LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP induced differentiation of TSH cells in a dose-dependent manner.

    In plain wordsIn cultured rat pituitary tissue, DSIP made more TSH-producing cells develop, and more so at higher doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTSH cell differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    Addition of DSIP during the first day of culture induced differentiation of LH and TSH cells only. The effect was dose-dependent.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).
  3. 03LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP induced lactotrope differentiation, but this effect may not be direct.

    In plain wordsIn cultured rat pituitary tissue, DSIP increased development of prolactin-producing cells, though the effect may be indirect.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLactotrope differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    DSIP also induced lactotrope differentiation, but this effect may not be direct.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).
  4. 04LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP had no effect on somatotrope differentiation.

    In plain wordsIn cultured rat pituitary tissue, DSIP did not change development of growth hormone-producing cells.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSomatotrope differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    DSIP had no effect on somatotrope and corticotrope differentiation.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).
  5. 05LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP had no effect on corticotrope differentiation.

    In plain wordsIn cultured rat pituitary tissue, DSIP did not change development of ACTH-producing cells.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCorticotrope differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    DSIP had no effect on somatotrope and corticotrope differentiation.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).
  6. 06LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP was less potent than GnRH in inducing LH and TSH cell differentiation.

    In plain wordsIn cultured rat pituitary tissue, DSIP was less potent than GnRH at inducing LH and TSH cell development.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePotency versus GnRH for LH and TSH cell differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Comparator
    GnRH (10(-9) M)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    DSIP was less potent than GnRH and as potent as TRH in inducing LH and TSH differentiation.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).
  7. 07LabEx vivo tissueEfficacy outcome

    In cultured rat fetal pituitary primordia, DSIP was as potent as TRH in inducing LH and TSH cell differentiation.

    In plain wordsIn cultured rat pituitary tissue, DSIP was as potent as TRH at inducing LH and TSH cell development.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePotency versus TRH for LH and TSH cell differentiation
    Study

    ratn: not reported in source

    Cultured pituitary primordia from 11-day-old rat fetuses
    Comparator
    TRH (10(-9) M)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    several concentrations · added to culture medium · first day of cultureAs given in this study (rat).

    Source sentences

    Summary
    DSIP was less potent than GnRH and as potent as TRH in inducing LH and TSH differentiation.
    1 context sentence
    Summary · context
    Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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