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Study · Animal study (in vivo) · rat · 1994

5 results

The effect of delta sleep-inducing peptide (DSIP) on the changes of body (core) temperature induced by serotonergic agonists in rats.

Tsunashima K, Kato N, Masui A, Takahashi K

Peptides1 Jan 1994Cited by 2 (Europe PMC)

PMID8015981 (opens in a new tab)DOI10.1016/0196-9781(94)90171-6 (opens in a new tab)PepBankPUB-08015981
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pretreatment with DSIP diminished the hyperthermia induced by high doses of 5-MeODMT.

    In plain wordsIn rats, DSIP given beforehand reduced the rise in body temperature caused by high doses of a serotonin-like drug.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseHyperthermia induced by high-dose 5-MeODMT
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hyperthermia induced by high doses of 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT) was diminished
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pretreatment with DSIP enhanced the hypothermia induced by low doses of 5-MeODMT.

    In plain wordsIn rats, DSIP given beforehand deepened the fall in body temperature caused by low doses of a serotonin-like drug.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseHypothermia induced by low-dose 5-MeODMT
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hypothermia induced by low doses of 5-MeODMT was enhanced by pretreatment with delta sleep-inducing peptide (DSIP).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP enhanced the hypothermia induced by 8-OH-DPAT.

    In plain wordsIn rats, DSIP deepened the fall in body temperature caused by a serotonin 1A receptor drug.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseHypothermia induced by 8-OH-DPAT
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delta sleep-inducing peptide had an enhancing effect of hypothermia induced by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, ICV injection of anti-DSIP completely inhibited the action of DSIP on temperature.

    In plain wordsIn rats, an antibody against DSIP, injected into the brain, fully blocked the temperature effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP enhancement of hypothermia with anti-DSIP
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This action of DSIP was completely inhibited by ICV injection of anti-DSIP.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, pindolol prevented the enhancing action of DSIP on hypothermia induced by 8-OH-DPAT and by apomorphine.

    In plain wordsIn rats, pindolol blocked the extra fall in body temperature that DSIP caused with two other drugs.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP enhancement of hypothermia with pindolol
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pindolol prevented the enhancing action of DSIP on both 8-OH-DPAT- and apomorphine-induced hypothermia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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