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Study · Animal study (in vivo) · rat · 1994

6 results

The effect of vasopressin and oxytocin on glomerular filtration rate in the conscious rat: contribution to the natriuretic response.

Forsling ML, Judah JM, Windle RJ

The Journal of endocrinology1 Apr 1994Cited by 23 (Europe PMC)

PMID8014603 (opens in a new tab)DOI10.1677/joe.0.1410059 (opens in a new tab)PepBankPUB-08014603
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, oxytocin infusion produced dose-dependent diuretic responses.

    In plain wordsIn conscious rats, oxytocin infusion increased urine flow in a dose-dependent way.

    Peptide
    Oxytocin
    Outcome
    IncreaseUrine flow
    Study

    ratn: not reported in source

    conscious unrestrained rats infused with hypotonic saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    30 and 200 pmol/min · infusionAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin produced dose-dependent diuretic and natriuretic responses.
    2 context sentences
    Summary · context
    The effects of vasopressin infused at 24 and 160 pmol/min and oxytocin infused at 30 and 200 pmol/min were determined.
    Summary · context
    Urine flow, sodium excretion, mean arterial blood pressure and glomerular filtration rate (GFR) were determined in the conscious unrestrained rat infused with hypotonic saline.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, oxytocin infusion produced dose-dependent natriuretic responses.

    In plain wordsIn conscious rats, oxytocin infusion increased sodium loss in urine in a dose-dependent way.

    Peptide
    Oxytocin
    Outcome
    IncreaseSodium excretion
    Study

    ratn: not reported in source

    conscious unrestrained rats infused with hypotonic saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    30 and 200 pmol/min · infusionAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin produced dose-dependent diuretic and natriuretic responses.
    2 context sentences
    Summary · context
    The effects of vasopressin infused at 24 and 160 pmol/min and oxytocin infused at 30 and 200 pmol/min were determined.
    Summary · context
    Urine flow, sodium excretion, mean arterial blood pressure and glomerular filtration rate (GFR) were determined in the conscious unrestrained rat infused with hypotonic saline.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, both oxytocin infusion rates increased the clearance of sodium.

    In plain wordsIn conscious rats, both oxytocin infusion rates increased how much sodium the kidneys cleared.

    Peptide
    Oxytocin
    Outcome
    IncreaseSodium clearance
    Study

    ratn: not reported in source

    conscious unrestrained rats infused with hypotonic saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    30 and 200 pmol/min · infusionAs given in this study (rat).

    Source sentences

    Summary
    Again both rates of infusion increased the clearance of sodium, but only the higher dose caused a significant increase in GFR.
    2 context sentences
    Summary · context
    The effects of vasopressin infused at 24 and 160 pmol/min and oxytocin infused at 30 and 200 pmol/min were determined.
    Summary · context
    Urine flow, sodium excretion, mean arterial blood pressure and glomerular filtration rate (GFR) were determined in the conscious unrestrained rat infused with hypotonic saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, the lower oxytocin infusion rate did not significantly increase glomerular filtration rate.

    In plain wordsIn conscious rats, the lower oxytocin dose did not significantly change kidney filtration rate.

    Peptide
    Oxytocin
    Outcome
    No significant changeGlomerular filtration rate at the lower dose
    Study

    ratn: not reported in source

    conscious unrestrained rats infused with hypotonic saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    30 pmol/min · infusionAs given in this study (rat).

    Source sentences

    Summary
    Again both rates of infusion increased the clearance of sodium, but only the higher dose caused a significant increase in GFR.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, the higher oxytocin infusion rate significantly increased glomerular filtration rate.

    In plain wordsIn conscious rats, the higher oxytocin dose significantly increased kidney filtration rate.

    Peptide
    Oxytocin
    Outcome
    IncreaseGlomerular filtration rate at the higher dose
    Study

    ratn: not reported in source

    conscious unrestrained rats infused with hypotonic saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    200 pmol/min · infusionAs given in this study (rat).

    Source sentences

    Summary
    Again both rates of infusion increased the clearance of sodium, but only the higher dose caused a significant increase in GFR.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, the lower oxytocin infusion rate significantly increased the fractional excretion of sodium.

    In plain wordsIn conscious rats, the lower oxytocin dose significantly increased the share of filtered sodium lost in urine.

    Peptide
    Oxytocin
    Outcome
    IncreaseFractional excretion of sodium at the lower dose
    Study

    ratn: not reported in source

    conscious unrestrained rats infused with hypotonic saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    30 pmol/min · infusionAs given in this study (rat).

    Source sentences

    Summary
    The lower dose caused a significant increase in the fractional excretion of sodium.
    2 context sentences
    Summary · context
    The effects of vasopressin infused at 24 and 160 pmol/min and oxytocin infused at 30 and 200 pmol/min were determined.
    Summary · context
    Urine flow, sodium excretion, mean arterial blood pressure and glomerular filtration rate (GFR) were determined in the conscious unrestrained rat infused with hypotonic saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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