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Study · Animal study (in vivo) · mouse · 1994

4 results

[Thymosin alpha-1 and hybrid proteins consisting of tumor necrosis factor-alpha and thymosin alpha-1 enhance the efficacy of vaccination against the causative agent of plague].

Shmelev VA, Grigor'ev BV, Mozharova TI, Popov SG

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 Jul 1994Cited by 1 (Europe PMC)

PMID7992547 (opens in a new tab)PepBankPUB-07992547
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In white mice exposed to sublethal doses of gamma radiation, recombinant thymosin alpha‑1 influenced the restoration of the immune system.

    In plain wordsIn mice exposed to radiation, recombinant thymosin alpha‑1 affected how the immune system recovered.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedImmune system restoration after gamma radiation
    Study

    mousen: not reported in source

    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The influence of rT on the restoration of the immune system of white mice after their exposure to sublethal doses of gamma radiation has been shown.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 02AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In mice and guinea pigs, thymosin alpha‑1 and its TNF hybrid proteins together enhanced specific immunity to Y. pestis when injected during vaccination.

    In plain wordsIn mice and guinea pigs, thymosin and its TNF hybrids together strengthened the immune response to a plague vaccine.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSpecific immunity after Y. pestis vaccination
    Study

    mouse; guinea pign: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The preparations of T and hybrid proteins exhibit immunostimulating action, enhancing specific immunity when injected at different periods of the vaccinal process against Y.pestis virulent strain 231 in experiments on mice and guinea pigs.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 03AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In mice and guinea pigs, the hybrid protein T-TNF-T gave the highest vaccination effectiveness and reproducibility among the preparations.

    In plain wordsIn mice and guinea pigs, the thymosin-TNF-thymosin hybrid worked best with the plague vaccine.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseEffectiveness and reproducibility of Y. pestis vaccination with T-TNF-T
    Study

    mouse; guinea pign: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The highest effectiveness and reproducibility of results is observed after the use of hybrid protein T-TNF-T.
    1 context sentence
    Summary · context
    The preparations of T and hybrid proteins exhibit immunostimulating action, enhancing specific immunity when injected at different periods of the vaccinal process against Y.pestis virulent strain 231 in experiments on mice and guinea pigs.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 04AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    The increase in immunity after the hybrid proteins was accompanied by activation of the T-cell element.

    In plain wordsIn animals, the stronger immunity after the hybrids went together with more active T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT-cell activation after hybrid protein use
    Study

    mouse; guinea pign: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    An increase in immunity after the use of the preparations of hybrid proteins is accompanied by the activation of its T-cell element.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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