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Study · Animal study (in vivo) · rat · 1994

3 results

Somatostatin analogue octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(alpha)anthracene-induced rat mammary carcinomas.

Weckbecker G, Tolcsvai L, Stolz B, Pollak M, Bruns C

Cancer research1 Dec 1994Cited by 65 (Europe PMC)

PMID7987824 (opens in a new tab)PepBankPUB-07987824
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mammary tumors, adding octreotide to tamoxifen reduced tumor number compared with tamoxifen alone.

    In plain wordsIn rats with mammary tumors, octreotide plus tamoxifen reduced tumor number compared with tamoxifen alone.

    Peptide
    Octreotide
    Outcome
    DecreaseTumor number
    Study

    ratn: not reported in source

    DMBA-induced mammary tumors
    Comparator
    Tamoxifen alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10 micrograms/kg/h · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    The number of tumors per animal and the sum of the volumes of palpable tumors per animal were significantly less in the combination treatment than in the others.
    1 context sentence
    Summary · context
    Rats received tamoxifen (0.5 mg/kg twice weekly s.c.), octreotide (10 micrograms/kg/h for 6 weeks by osmotic minipump), or the combination 7 weeks following 7,12-dimethylbenz(alpha)anthracene administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mammary tumors, adding octreotide to tamoxifen reduced total palpable tumor volume compared with tamoxifen alone.

    In plain wordsIn rats with mammary tumors, octreotide plus tamoxifen reduced tumor volume compared with tamoxifen alone.

    Peptide
    Octreotide
    Outcome
    DecreaseTotal palpable tumor volume
    Study

    ratn: not reported in source

    DMBA-induced mammary tumors
    Comparator
    Tamoxifen alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10 micrograms/kg/h · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    The number of tumors per animal and the sum of the volumes of palpable tumors per animal were significantly less in the combination treatment than in the others.
    1 context sentence
    Summary · context
    Rats received tamoxifen (0.5 mg/kg twice weekly s.c.), octreotide (10 micrograms/kg/h for 6 weeks by osmotic minipump), or the combination 7 weeks following 7,12-dimethylbenz(alpha)anthracene administration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, continuous octreotide infusion suppressed mammary tumor regrowth (P < 0.01).

    In plain wordsIn rats after ovary removal, octreotide suppressed tumor regrowth compared with ovary removal alone.

    Peptide
    Octreotide
    Outcome
    DecreaseTumor regrowth after ovariectomy
    Study

    ratn: not reported in source

    DMBA-induced mammary tumors
    Comparator
    Ovariectomy alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    50 micrograms/kg/h · continuous infusion · 6 weeks postovariectomyAs given in this study (rat).

    Source sentences

    Summary
    However, continuous infusion of octreotide (50 micrograms/kg/h for 6 weeks postovariectomy) significantly (P < 0.01) suppressed this regrowth.
    2 context sentences
    Summary · context
    In ovariectomized rats the marked regression of established tumors in the initial 4 weeks after ovariectomy was frequently followed by tumor regrowth.
    Summary · context
    Rats received tamoxifen (0.5 mg/kg twice weekly s.c.), octreotide (10 micrograms/kg/h for 6 weeks by osmotic minipump), or the combination 7 weeks following 7,12-dimethylbenz(alpha)anthracene administration.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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