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Study · Ex vivo tissue · rat · 1994

4 results

Effects of thymulin on in vitro incorporation of 3H-thymidine into gonocytes of newborn rat testes.

Prépin J, Le Vigouroux P, Dadoune JP

Reproduction, nutrition, development1 Jan 1994Cited by 5 (Europe PMC)

PMID7986347 (opens in a new tab)DOI10.1051/rnd:19940402 (opens in a new tab)PepBankPUB-07986347
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In newborn rat testis cultures, thymulin did not affect gonocyte thymidine incorporation on days 0, 1 and 7 versus untreated cultures.

    In plain wordsIn lab tests, thymulin did not change DNA labeling versus untreated rat testis cultures on days 0, 1 and 7.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeGonocyte thymidine incorporation on days 0, 1 and 7
    Study

    ratn: not reported in source

    organ cultures of newborn rat testes
    Comparator
    cultures without thymulin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The data indicated that thymulin had no effect on gonocyte incorporation on day 0 or on days 1 and 7; in contrast, thymulin had a strong effect on day 2.
    1 context sentence
    Summary · context
    3H-Thymidine incorporation into gonocytes was investigated by means of quantitative autoradiography in organ cultures of testes from newborn rats between day 0 (day of birth) and day 7, in the presence or absence of thymulin.
  2. 02LabEx vivo tissueMechanism

    In newborn rat testis cultures, the percentage of labeled gonocytes was 10-fold higher with thymulin than in controls on day 2.

    In plain wordsIn lab tests, thymulin increased the percentage of DNA-labeled rat germ cells 10-fold versus controls on day 2.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseLabeled gonocytes on day 2
    Study

    ratn: not reported in source

    organ cultures of newborn rat testes
    Comparator
    cultures without thymulin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Percentage of labeled gonocytes
    10 fold higher
    thymulin versus controls on day 2

    Source sentences

    Summary
    At day 2 the percentage of labeled gonocytes was 10-fold higher in experimental animals than in controls.
    1 context sentence
    Summary · context
    3H-Thymidine incorporation into gonocytes was investigated by means of quantitative autoradiography in organ cultures of testes from newborn rats between day 0 (day of birth) and day 7, in the presence or absence of thymulin.
  3. 03LabEx vivo tissueMechanism

    In newborn rat testis cultures, thymulin showed moderate activity on gonocyte thymidine incorporation between days 2 and 6.

    In plain wordsIn lab tests, thymulin moderately increased DNA labeling compared with untreated rat testis cultures between days 2 and 6.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseGonocyte thymidine incorporation between days 2 and 6
    Study

    ratn: not reported in source

    organ cultures of newborn rat testes
    Comparator
    cultures without thymulin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Between days 2 and 6, thymulin had moderate activity.
    1 context sentence
    Summary · context
    3H-Thymidine incorporation into gonocytes was investigated by means of quantitative autoradiography in organ cultures of testes from newborn rats between day 0 (day of birth) and day 7, in the presence or absence of thymulin.
  4. 04LabEx vivo tissueMechanism

    In newborn rat testis cultures exposed to thymulin, mitoses remained low despite high thymidine incorporation.

    In plain wordsIn lab tests, rat germ cell division remained low after thymulin exposure despite high DNA labeling.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedGonocyte mitoses
    Study

    ratn: not reported in source

    organ cultures of newborn rat testes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, in spite of a high incorporation rate of 3H-thymidine into gonocytes after incubation with thymulin, the number of mitoses remained low, suggesting that thymulin may affect DNA duplication in gonocytes of newborn rat testes.
    1 context sentence
    Summary · context
    3H-Thymidine incorporation into gonocytes was investigated by means of quantitative autoradiography in organ cultures of testes from newborn rats between day 0 (day of birth) and day 7, in the presence or absence of thymulin.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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