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Study · Not a test of the peptide alone · 1994

2 results

Postoperative acute adrenal failure caused by transient corticotropin deficiency.

Merry WH, Caplan RH, Wickus GG, Reynertson RH, Kisken WA, Cogbill TH, Landercasper J

Surgery1 Dec 1994Cited by 21 (Europe PMC)

PMID7985093 (opens in a new tab)PepBankPUB-07985093
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In postoperative patients with evidence of corticotropin deficiency, standard-dose cosyntropin produced normal responses.

    In plain wordsIn postoperative patients with evidence of corticotropin deficiency, standard-dose cosyntropin gave normal results.

    Peptide
    Cosyntropin
    Outcome
    Not applicableStandard-dose cosyntropin false-normal response
    Study

    n = 5

    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Source sentences

    Summary
    We identified five (5%) of 105 patients after an operation who displayed evidence of corticotropin deficiency (i.e., serum cortisol < 15 micrograms/dl during hypotension, prompt hemodynamic improvement with glucocorticoid therapy, and normal response to standard dose cosyntropin).
    1 context sentence
    Summary · context
    In this study we measured serum cortisol in patients older than 65 years who had unexplained hypotension after an abdominal surgical procedure. If the serum cortisol was less than 15 micrograms/dl, we performed 1 microgram and standard (250 micrograms) cosyntropin tests and measured thyroxine, thyro…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In postoperative patients with evidence of corticotropin deficiency, low-dose cosyntropin produced abnormal peak cortisol despite normal standard-dose responses.

    In plain wordsIn postoperative patients with corticotropin deficiency, low-dose cosyntropin gave abnormal results despite normal standard-dose results.

    Peptide
    Cosyntropin
    Outcome
    Not applicableLow-dose cosyntropin abnormal response
    Study

    n = 5

    Comparator
    Standard-dose cosyntropin
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Source sentences

    Summary
    In these patients 1 microgram cosyntropin produced abnormal peak cortisol levels.
    2 context sentences
    Summary · context
    We identified five (5%) of 105 patients after an operation who displayed evidence of corticotropin deficiency (i.e., serum cortisol < 15 micrograms/dl during hypotension, prompt hemodynamic improvement with glucocorticoid therapy, and normal response to standard dose cosyntropin).
    Summary · context
    In this study we measured serum cortisol in patients older than 65 years who had unexplained hypotension after an abdominal surgical procedure. If the serum cortisol was less than 15 micrograms/dl, we performed 1 microgram and standard (250 micrograms) cosyntropin tests and measured thyroxine, thyro…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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