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Study · Animal study (in vivo) · rat · 1994

4 results

Oxytocin augments baroreflex bradycardia in conscious rats.

Russ RD, Walker BR

Peptides1 Jan 1994Cited by 17 (Europe PMC)

PMID7984512 (opens in a new tab)DOI10.1016/0196-9781(94)90049-3 (opens in a new tab)PepBankPUB-07984512
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, oxytocin infused at a dose with no effect on baseline hemodynamics augmented the bradycardic response to methoxamine.

    In plain wordsIn conscious rats, oxytocin made the heart-rate slowing response to a blood-pressure-raising drug stronger.

    Peptide
    Oxytocin
    Outcome
    IncreaseBaroreflex bradycardia response to methoxamine
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Infusion of oxytocin at a dose that had no effect on baseline hemodynamic values significantly augmented the bradycardic response to IV bolus doses of methoxamine.
    1 context sentence
    Summary · context
    In the present study, experiments were performed in conscious rats to determine the possible involvement of oxytocin receptors in this response.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In conscious rats, prior treatment with antagonists to oxytocin, V1 or V2 receptors reversed the oxytocin enhancement of the bradycardic response.

    In plain wordsIn conscious rats, drugs blocking oxytocin or vasopressin receptors removed the stronger heart-rate slowing seen with oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableReversal of oxytocin augmentation of baroreflex bradycardia by receptor antagonists
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Prior treatment with selective antagonists to either oxytocin, V1 vasopressinergic or V2 vasopressinergic receptors reversed this enhancement.
    2 context sentences
    Summary · context
    Infusion of oxytocin at a dose that had no effect on baseline hemodynamic values significantly augmented the bradycardic response to IV bolus doses of methoxamine.
    Summary · context
    In the present study, experiments were performed in conscious rats to determine the possible involvement of oxytocin receptors in this response.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, combined arginine vasopressin and oxytocin did not augment baroreflex-mediated bradycardia more than arginine vasopressin alone.

    In plain wordsIn conscious rats, giving oxytocin together with vasopressin did not strengthen heart-rate slowing more than vasopressin alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeCombined vasopressin and oxytocin effect on baroreflex bradycardia
    Study

    ratn: not reported in source

    conscious rats
    Comparator
    Vasopressin alone
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with both AVP and oxytocin did not augment baroreflex-mediated bradycardia greater than AVP alone.
    1 context sentence
    Summary · context
    In the present study, experiments were performed in conscious rats to determine the possible involvement of oxytocin receptors in this response.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, oxytocin infused at the studied dose had no effect on baseline hemodynamic values.

    In plain wordsIn conscious rats, the oxytocin dose used did not change baseline hemodynamic measures.

    Peptide
    Oxytocin
    Outcome
    No significant changeBaseline hemodynamic values during oxytocin infusion
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Infusion of oxytocin at a dose that had no effect on baseline hemodynamic values significantly augmented the bradycardic response to IV bolus doses of methoxamine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

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