Skip to content

Study · In vitro (cells) · 1994

2 results

Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.

Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T, Gantz I

Biochemical and biophysical research communications1 Nov 1994Cited by 32 (Europe PMC)

PMID7980588 (opens in a new tab)DOI10.1006/bbrc.1994.2581 (opens in a new tab)PepBankPUB-07980588
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    MT-II bound the human MC1 receptor with an IC50 of 0.57 +/- 0.08 x 10(-9) M.

    In plain wordsIn cells, MT-II bound the human MC1 receptor strongly, at a sub-nanomolar concentration.

    Peptide
    Melanotan II
    Outcome
    Not applicablehMC1R binding IC50
    Study

    humann: not reported in source

    Cloned human melanocortin receptor hMC1R
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Binding IC50
    0.57 nM
    hMC1R

    Source sentences

    Summary
    MT-II possesses a binding IC50 of 0.57 +/- 0.08 x 10(-9) M and cAMP EC50 value of 0.20 +/- 0.05 x 10(-9) M.
    1 context sentence
    Title · context
    Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.
  2. 02LabIn vitro (cells)Activity measurement

    MT-II stimulated cAMP through the human MC1 receptor with an EC50 of 0.20 +/- 0.05 x 10(-9) M.

    In plain wordsIn cells, MT-II switched on the human MC1 receptor signal at a sub-nanomolar concentration.

    Peptide
    Melanotan II
    Outcome
    Not applicablehMC1R cAMP stimulation EC50
    Study

    humann: not reported in source

    Cloned human melanocortin receptor hMC1R
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    cAMP EC50
    0.2 nM
    hMC1R

    Source sentences

    Summary
    MT-II possesses a binding IC50 of 0.57 +/- 0.08 x 10(-9) M and cAMP EC50 value of 0.20 +/- 0.05 x 10(-9) M.
    1 context sentence
    Title · context
    Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.