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Study · Animal study (in vivo) · rat · 1994

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Preparation of three-month depot injectable microspheres of leuprorelin acetate using biodegradable polymers.

Okada H, Doken Y, Ogawa Y, Toguchi H

Pharmaceutical research1 Aug 1994Cited by 134 (Europe PMC)

PMID7971715 (opens in a new tab)DOI10.1023/a:1018936815654 (opens in a new tab)PepBankPUB-07971715
Publisher pagePubMedAsk about this study
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, leuprorelin microspheres made with PLA of molecular weight 12,000 to 18,000 provided linear release and persistent serum levels for over 3 months.

    In plain wordsIn rats, leuprorelin acetate-loaded PLA microspheres provided linear release and persistent serum drug levels for over 3 months.

    Peptide
    Leuprolide
    Outcome
    Not applicableSustained release and persistent serum drug levels
    Study

    ratn: not reported in source

    Rats receiving leuprorelin acetate microspheres
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Polymer molecular weight
    12,000 to 18,000
    PLA
    Persistent serum levels duration
    > 3 months
    rats

    Source sentences

    Summary
    The microspheres prepared with PLA having a m.w. of 12,000 to 18,000 provided linear sustained release and persistent serum levels of the drug in rats for over 3 months.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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