Skip to content

Study · Animal study (in vivo) · rat · 1994

4 results

Growth hormone-releasing hexapeptide is a potent stimulator of growth hormone gene expression and release in the growth hormone-releasing hormone-deprived infant rat.

Locatelli V, Grilli R, Torsello A, Cella SG, Wehrenberg WB, Müller EE

Pediatric research1 Aug 1994Cited by 19 (Europe PMC)

PMID7970930 (opens in a new tab)DOI10.1203/00006450-199408000-00006 (opens in a new tab)PepBankPUB-07970930
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In infant rats, GHRP‑6 increased plasma GH dose-dependently, with maximal stimulation at 300 micrograms/kg.

    In plain wordsIn rats, GHRP‑6 increased blood growth hormone in a dose-dependent manner.

    Peptide
    GHRP-6
    Outcome
    IncreasePlasma GH
    Study

    ratn: not reported in source

    14-d-old rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    32-600 micrograms/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In 14-d-old rats GHRP-6 (32-600 micrograms/kg, s.c.) induced a marked and dose-dependent rise in plasma GH concentrations, maximal stimulation occurring with the dose of 300 micrograms/kg.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In GHRH-deprived rat pups, GHRP‑6 completely counteracted the inhibition of GH mRNA expression.

    In plain wordsIn rats deprived of GHRH, GHRP‑6 counteracted the reduction in growth hormone gene expression.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH mRNA expression
    Study

    ratn: not reported in source

    GHRH-deprived rat pups
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    80 micrograms/kg twice daily · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In pups passively immunized with GHRH antibodies, a 5-d treatment with GHRP-6 (80 micrograms/kg, s.c., twice daily) completely counteracted the inhibitory effect of GHRH deprivation on GH mRNA expression.
  3. 03LabIn vitro (cells)Mechanism

    In cultured rat pituitary cells, GHRP‑6 caused small, transient stimulation of GH release.

    In plain wordsIn cells from rats, GHRP‑6 briefly increased growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    ratn: not reported in source

    cultured pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-7) and 10(-6) MAs given in this study (rat).

    Source sentences

    Summary
    In vitro GHRP-6 (10(-7) and 10(-6) M) induced a small and transient stimulation of GH release from cultured pituitary cells.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In infant rats, neither GHRH nor somatostatin antiserum modified GHRP‑6-induced GH release.

    In plain wordsIn rats, neither GHRH nor somatostatin antiserum changed GHRP‑6-induced growth hormone release.

    Peptide
    GHRP-6
    Outcome
    No significant changeAntiserum modification of GH release
    Study

    ratn: not reported in source

    infant rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Neither GHRH nor somatostatin antiserum prevented or modified the GH release elicited by GHRP-6.
    1 context sentence
    Summary · context
    To gain more insight into the mechanism(s) of action of GHRP-6, we studied the infant rat, an animal model highly responsive to GH-releasing stimuli.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.