In suckling rat jejunal explants, des-(1-3)IGF-I had no effect on morphology after 24 or 48 h culture.
In plain wordsIn lab tests with rat intestine, des-(1-3)IGF-I did not change tissue morphology.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- No significant changeExplant morphology
- Study
ratn: not reported in source
Suckling rat jejunal explants- Outcome group
- Gastrointestinal protection · Gastrointestinal
- Studied dose
- Dose not stated · 24 or 48 hAs given in this study (rat).
Source sentences
IGF-I and IGF-II, des-(1-3)IGF-I, fibroblast growth factor (FGF), and growth hormone (GH) had no effect on morphology or biochemical activity of explants after 24 or 48 h culture.(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
To facilitate the study of regulators of differentiation and proliferation of small intestinal epithelium in the suckling rat we have developed a serum-free organ culture system and used it to examine epithelial responsiveness to various regulatory hormones.
Tissue responsiveness to various regulatory hormones was then tested in the serum-free medium.