Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging.

Ghigo E, Arvat E, Rizzi G, Goffi S, Grottoli S, Mucci M, Boghen MF, Camanni F

European journal of endocrinology1 Nov 1994Cited by 16 (Europe PMC)

PMID7952160DOI10.1530/eje.0.1310499PepBankPUB-07952160

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialEfficacy outcome
In normal elderly women, oral GHRP‑6 before treatment raised GH more than intravenous GHRH.
In plain wordsIn healthy elderly women, a single oral dose of GHRP‑6 raised growth hormone more than injected GHRH.
Peptide
GHRP-6
Outcome
IncreaseGH response to oral GHRP-6 versus intravenous GHRH before treatment
Study
n = 7
Comparator
Intravenous GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
300 micrograms/kg · oralAs given in this study (human).
Measurements
GH peak
10.7 micrograms/l
oral GHRP-6
GH peak
5.1 micrograms/l
intravenous GHRH
Source sentences
Summary
Before treatment, oral administration of 300 micrograms/kg GHRP-6 elicited a clear GH rise (peak 10.7 +/- 3.3 micrograms/l; AUC 353.1 +/- 90.6 micrograms.l-1.h-1), which was significantly higher (p < 0.01) than that induced by intravenous GHRH (peak 5.1 +/- 1.5 micrograms/l; AUC 106.5 +/- 43.9 micrograms.l-1.h-1).
2 context sentences(design, population, supporting numbers)
Summary · context
Seven normal elderly women (aged 65-82 years) were studied.
Summary · context
The effect of oral administration of 300 micrograms/kg GHRP-6 on GH secretion was investigated before and after 4 days of treatment with the hexapeptide given twice daily.
Report a problemFND-0795216001
02HumanNon-randomized trialEfficacy outcome
In normal elderly women, the GH response to oral GHRP‑6 was maintained after 4 days of twice-daily treatment, with a trend towards an increase.
In plain wordsIn healthy elderly women, the growth hormone response to oral GHRP‑6 stayed the same after 4 days of use.
Peptide
GHRP-6
Outcome
No significant changeGH response to oral GHRP-6 after 4 days of treatment
Study
n = 7
Comparator
Before treatment
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
300 micrograms/kg · oral · 4 daysAs given in this study (human).
Measurements
GH peak
16.8 micrograms/l
after 4 days
Source sentences
Summary
After 4 days of treatment with GHRP-6, the GH response to the hexapeptide was maintained, with a trend towards an increase (peak 16.8 +/- 2.9 micrograms/l; AUC 499.8 +/- 107.2 micrograms.l-1.h-1).
2 context sentences(design, population, supporting numbers)
Summary · context
Seven normal elderly women (aged 65-82 years) were studied.
Summary · context
The effect of oral administration of 300 micrograms/kg GHRP-6 on GH secretion was investigated before and after 4 days of treatment with the hexapeptide given twice daily.
Report a problemFND-0795216002
03HumanNon-randomized trialEfficacy outcome
In normal elderly women, IGF-I levels did not increase significantly after 4 days of oral GHRP‑6.
In plain wordsIn healthy elderly women, 4 days of oral GHRP‑6 did not significantly raise IGF-I levels.
Peptide
GHRP-6
Outcome
No significant changeIGF-I level after 4 days of treatment
Study
n = 7
Comparator
Before treatment
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
300 micrograms/kg · oral · 4 daysAs given in this study (human).
Measurements
IGF-I
77.1 micrograms/l
before treatment
IGF-I
84.1 micrograms/l
after treatment
Source sentences
Summary
The IGF-I levels were not increased significantly after treatment (77.1 +/- 8.4 vs 84.1 +/- 12.2 micrograms/l)
2 context sentences(design, population, supporting numbers)
Summary · context
Seven normal elderly women (aged 65-82 years) were studied.
Summary · context
The effect of oral administration of 300 micrograms/kg GHRP-6 on GH secretion was investigated before and after 4 days of treatment with the hexapeptide given twice daily.
Report a problemFND-0795216003

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.