Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat.

Jansson L

Acta diabetologica1 Jun 1994Cited by 10 (Europe PMC)

PMID7949220DOI10.1007/bf00570545PepBankPUB-07949220

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, intravenous VIP markedly increased whole pancreatic blood flow.
In plain wordsIn rats, VIP markedly increased blood flow through the whole pancreas.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseWhole pancreatic blood flow
Study
ratn: not reported in source
Outcome group
Vascular function · Cardiovascular
Studied dose
500 ng/kg body weight · intravenous · 90 sAs given in this study (rat).
Source sentences
Title
Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat.
2 context sentences(design, population, supporting numbers)
Summary · context
VIP markedly increased the former but did not affect the latter.
Summary · context
To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight).
Report a problemFND-0794922001
02AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, intravenous VIP did not affect islet blood flow.
In plain wordsIn rats, VIP did not change blood flow through the pancreatic islets.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeIslet blood flow
Study
ratn: not reported in source
Outcome group
Vascular function · Cardiovascular
Studied dose
500 ng/kg body weight · intravenous · 90 sAs given in this study (rat).
Source sentences
Title
Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat.
2 context sentences(design, population, supporting numbers)
Summary · context
VIP markedly increased the former but did not affect the latter.
Summary · context
To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight).
Report a problemFND-0794922002
03AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, VIP decreased the fraction of whole pancreatic blood flow diverted through the islets.
In plain wordsIn rats, VIP lowered the share of pancreatic blood flow that goes through the islets.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseFraction of pancreatic blood flow through the islets
Study
ratn: not reported in source
Outcome group
Vascular function · Cardiovascular
Studied dose
500 ng/kg body weight · intravenous · 90 sAs given in this study (rat).
Source sentences
Summary
Thus, the fraction of the whole pancreatic blood flow diverted through the islets was decreased.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight).
Report a problemFND-0794922003
04AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, VIP caused an acute increase in serum insulin concentration after 2 min.
In plain wordsIn rats, VIP quickly raised the insulin level in the blood.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSerum insulin concentration
Study
ratn: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Studied dose
500 ng/kg body weight · intravenous · 90 sAs given in this study (rat).
Source sentences
Summary
In separate experiments, the effects of VIP on the blood glucose and serum insulin concentrations of anaesthetized animals were investigated. VIP caused an acute increase (after 2 min) in the latter, but did not affect the former.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight).
Report a problemFND-0794922004
05AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, VIP did not affect blood glucose concentration.
In plain wordsIn rats, VIP did not change the blood glucose level.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeBlood glucose concentration
Study
ratn: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Studied dose
500 ng/kg body weight · intravenous · 90 sAs given in this study (rat).
Source sentences
Summary
In separate experiments, the effects of VIP on the blood glucose and serum insulin concentrations of anaesthetized animals were investigated. VIP caused an acute increase (after 2 min) in the latter, but did not affect the former.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight).
Report a problemFND-0794922005

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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