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Study · Animal study (in vivo) · dog · 1994

10 results

AICA riboside improves myocardial ischemia in coronary microembolization in dogs.

Hori M, Kitakaze M, Takashima S, Morioka T, Sato H, Minamino T, Node K, Komamura K, Inoue M, Kamada T

The American journal of physiology1 Oct 1994Cited by 5 (Europe PMC)

PMID7943395 (opens in a new tab)DOI10.1152/ajpheart.1994.267.4.h1483 (opens in a new tab)PepBankPUB-07943395
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In dogs with coronary microembolization, AICA riboside increased coronary hyperemia versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside increased coronary blood flow compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCoronary hyperemia
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Coronary blood flow
    187 ml.100 g-1.min-1
    AICA riboside
    Reported uncertainty
    8 ml.100 g-1.min-1
    type not stated
    P value
    < 0.05 NA
    versus control

    Source sentences

    Summary
    Administration of AICA riboside (n = 5) enhanced coronary hyperemia (187 +/- 8 ml.100 g-1.min-1, P < 0.05)
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, AICA riboside increased myocardial adenosine release versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside increased adenosine release from heart muscle compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAdenosine release
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Adenosine release
    11.9 nmol.100 g-1.min-1
    AICA riboside
    Reported uncertainty
    0.9 nmol.100 g-1.min-1
    type not stated
    P value
    < 0.001 NA
    versus control

    Source sentences

    Summary
    adenosine release (11.9 +/- 0.9 nmol.100 g-1.min-1, P < 0.001)
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, AICA riboside increased myocardial adenosine content versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside increased adenosine in heart muscle compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMyocardial adenosine content
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Myocardial adenosine content
    0.434 nmol/mg wet wt
    AICA riboside
    Myocardial adenosine content
    0.118 nmol/mg wet wt
    control
    P value
    < 0.01 NA
    versus control

    Source sentences

    Summary
    and myocardial adenosine content (0.434 +/- 0.069 vs. 0.118 +/- 0.019 nmol/mg wet wt, P < 0.01)
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In dogs with coronary microembolization, AICA riboside attenuated the decrease in fractional shortening versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside reduced the loss of heart muscle shortening compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseFractional shortening
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and attenuated decreases in fractional shortening and lactate extraction ratio.
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, AICA riboside attenuated the decrease in lactate extraction ratio versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside reduced the fall in heart lactate extraction compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLactate extraction ratio
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and attenuated decreases in fractional shortening and lactate extraction ratio.
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, AICA riboside increased ectosolic nucleotidase activity in embolized myocardium versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside increased ectosolic nucleotidase activity in affected heart muscle compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEctosolic nucleotidase activity
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, AICA riboside increased ectosolic and cytosolic 5'-nucleotidase activity of the embolized myocardium (n = 12).
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, AICA riboside increased cytosolic nucleotidase activity in embolized myocardium versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside increased cytosolic nucleotidase activity in affected heart muscle compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCytosolic nucleotidase activity
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, AICA riboside increased ectosolic and cytosolic 5'-nucleotidase activity of the embolized myocardium (n = 12).
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, AICA riboside preserved myocardial tissue ATP content versus control.

    In plain wordsIn dogs with coronary microembolization, AICA riboside preserved ATP in the affected heart tissue compared with control.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMyocardial ATP content
    Study

    dogn: not reported in source

    Acute coronary microembolization
    Comparator
    Control without AICA riboside
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICA riboside preserved myocardial tissue ATP content of the embolized area.
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 09AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, 8-phenyltheophylline abolished the beneficial effects of AICA riboside.

    In plain wordsIn dogs with coronary microembolization, 8-phenyltheophylline blocked AICA riboside's benefits compared with AICA riboside alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBeneficial effects blocked by 8-phenyltheophylline
    Study

    dogn = 12

    Acute coronary microembolization
    Comparator
    AICA riboside without 8-phenyltheophylline
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    The administrations of 8-phenyltheophylline (n = 12) and alpha,beta-methyleneadenosine 5'-diphosphate (n = 10) abolished the beneficial effects of AICA riboside.
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 10AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In dogs with coronary microembolization, alpha,beta-methyleneadenosine diphosphate abolished the beneficial effects of AICA riboside.

    In plain wordsIn dogs with coronary microembolization, alpha,beta-methyleneadenosine diphosphate blocked AICA riboside's benefits compared with AICA riboside alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBeneficial effects blocked by alpha,beta-methyleneadenosine diphosphate
    Study

    dogn = 10

    Acute coronary microembolization
    Comparator
    AICA riboside without alpha,beta-methyleneadenosine diphosphate
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    The administrations of 8-phenyltheophylline (n = 12) and alpha,beta-methyleneadenosine 5'-diphosphate (n = 10) abolished the beneficial effects of AICA riboside.
    2 context sentences
    Summary · context
    The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured.
    Summary · context
    Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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