In hairless mouse skin in vitro, iontophoretic nafarelin delivery could neutralize skin permselectivity.
In plain wordsIn lab tests with hairless mouse skin, nafarelin delivery by electric current could neutralize skin transport selectivity.
- Peptide
- Nafarelin
- Outcome
- Not applicableSkin permselectivity
- Study
mousen: not reported in source
Hairless mouse skin in vitro- Outcome group
- Drug transport · Pharmacology
- Studied dose
- Dose not stated · iontophoresisAs given in this study (mouse).
Source sentences
(c) The permselectivity of skin can be 'neutralized' by driving, iontophoretically, a cationic, lipophilic peptide (specifically the leutinizing hormone releasing hormone (LHRH) analog, Nafarelin) into the membrane.
1 context sentence(design, population, supporting numbers)
Electroosmosis was assessed from the iontophoreically driven fluxes of mannitol, sucrose and lactose across hairless mouse skin in vitro.