Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors.

Virgolini I, Raderer M, Kurtaran A, Angelberger P, Banyai S, Yang Q, Li S, Banyai M, Pidlich J, Niederle B, Scheithauer W, Valent P

The New England journal of medicine1 Oct 1994Cited by 136 (Europe PMC)

PMID7935635DOI10.1056/nejm199410273311703PepBankPUB-07935635

Publisher page PubMedAsk about this study

Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 12 results from people.

01HumanNon-randomized trialOther
123I-VIP imaging visualized primary pancreatic adenocarcinoma in 10 of 12 patients.
In plain wordsA scan with radioactive VIP showed the pancreatic tumor in 10 of 12 patients.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of primary pancreatic adenocarcinoma by 123I-VIP scan
Study
n = 12
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
Primary pancreatic adenocarcinomas were visualized by imaging in 10 of 12 patients
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563505
02HumanNon-randomized trialOther
123I-VIP scans were positive in 9 of 10 patients with carcinoid tumors.
In plain wordsA scan with radioactive VIP was positive in 9 of 10 patients with carcinoid tumors.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of carcinoid tumors by 123I-VIP scan
Study
n = 10
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
VIP scans were positive in 9 of 10 patients with carcinoid tumors
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563509
03HumanNon-randomized trialOther
123I-VIP scanning visualized primary or recurrent gastric adenocarcinoma in 5 of 5 patients.
In plain wordsA scan with radioactive VIP showed the stomach tumor in all 5 patients.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of primary or recurrent gastric adenocarcinoma by 123I-VIP scan
Study
n = 5
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
Primary or recurrent gastric adenocarcinomas were visualized in 5 of 5 patients
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563507
04HumanNon-randomized trialOther
123I-VIP scans were positive in 4 of 4 patients with insulinomas.
In plain wordsA scan with radioactive VIP was positive in all 4 patients with insulinoma.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of insulinomas by 123I-VIP scan
Study
n = 4
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
in 4 of 4 patients with insulinomas.
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563510
05HumanNon-randomized trialOther
In gastric adenocarcinoma, 123I-VIP scanning showed liver metastases in 2 of 2 patients.
In plain wordsA scan with radioactive VIP showed liver metastases in both 2 patients with stomach cancer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of gastric cancer liver metastases by 123I-VIP scan
Study
n = 2
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
liver metastases were seen in 2 of 2 patients.
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563508
06HumanNon-randomized trialOther
In patients with colorectal adenocarcinoma, 123I-VIP scanning visualized primary or recurrent tumors in 10 of 10.
In plain wordsA scan with radioactive VIP showed primary or recurrent bowel tumors in 10 of 10 patients with colorectal cancer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of colorectal primary or recurrent tumors by 123I-VIP scan
Study
n: not reported in source
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
In patients with colorectal adenocarcinomas, primary or recurrent tumors were visualized in 10 of 10
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563501
07HumanNon-randomized trialOther
In patients with colorectal adenocarcinoma, 123I-VIP scanning visualized liver metastases in 15 of 18.
In plain wordsA scan with radioactive VIP showed 15 of 18 liver metastases from colorectal cancer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of colorectal liver metastases by 123I-VIP scan
Study
n: not reported in source
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
liver metastases in 15 of 18
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563502
08HumanNon-randomized trialOther
In patients with colorectal adenocarcinoma, 123I-VIP scanning visualized lung metastases in 2 of 3.
In plain wordsA scan with radioactive VIP showed 2 of 3 lung metastases from colorectal cancer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of colorectal lung metastases by 123I-VIP scan
Study
n: not reported in source
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
lung metastases in 2 of 3
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563503
09HumanNon-randomized trialOther
In patients with colorectal adenocarcinoma, 123I-VIP scanning visualized lymph-node metastases in 4 of 4.
In plain wordsA scan with radioactive VIP showed all 4 lymph-node metastases from colorectal cancer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of colorectal lymph-node metastases by 123I-VIP scan
Study
n: not reported in source
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
lymph-node metastases in 4 of 4
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563504
10HumanNon-randomized trialOther
In pancreatic adenocarcinoma, 123I-VIP imaging showed liver metastases in 7 of 7.
In plain wordsA scan with radioactive VIP showed liver metastases in 7 of 7 cases of pancreatic cancer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDetection of pancreatic cancer liver metastases by 123I-VIP scan
Study
n: not reported in source
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
liver metastases were seen in 7 of 7.
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563506
11HumanNon-randomized trialPharmacokinetics
Binding of radiolabeled VIP by primary tumors and metastases was visible shortly after injection and still demonstrable at 24 hours.
In plain wordsRadioactive VIP was seen in tumors soon after injection and was still visible 24 hours later.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableTime course of radiolabeled VIP binding in tumors
Study
n: not reported in source
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
Binding of the labeled peptide by primary tumors and metastases was visible shortly after the injection and was still demonstrable at 24 hours.
2 context sentences(design, population, supporting numbers)
Summary · context
Radioiodinated VIP was purified by high-pressure liquid chromatography and administered as a single intravenous bolus injection (300 pmol [1 microgram]).
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563511
12HumanNon-randomized trialOther
Among tumors with positive 123I-VIP scans, scanning with somatostatin analogues also visualized 4 of 17 colorectal adenocarcinomas, 8 of 9 carcinoids and 2 of 2 insulinomas.
In plain wordsOf tumors seen on the VIP scan, other scans also showed 4 of 17 colorectal, 8 of 9 carcinoid and 2 of 2 insulinoma.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableTumors with positive 123I-VIP scan also visualized by somatostatin analogue scanning
Study
n: not reported in source
Comparator
Scanning with somatostatin analogues
Outcome group
Diagnostic imaging · Cancer
Studied dose
300 pmol (1 microgram) · intravenous bolusAs given in this study (human).
Source sentences
Summary
Some tumors with positive VIP scans were also visualized with somatostatin analogues (4 of 17 colorectal adenocarcinomas, 8 of 9 carcinoids, and 2 of 2 insulinomas).
1 context sentence(design, population, supporting numbers)
Summary · context
Scanning with radiolabeled VIP was compared with computed tomography and scanning with somatostatin analogues in 79 patients with colorectal cancer, pancreatic carcinoma, gastric cancer, carcinoid tumor, or insulinoma.
Report a problemFND-0793563513
13LabEx vivo tissueActivity measurement
In-vitro binding studies confirmed that VIP receptors are present on gastrointestinal tumors.
In plain wordsIn lab tests, VIP binding sites were found on gastrointestinal tumors.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP receptors on gastrointestinal tumors (in vitro binding)
Study
n: not reported in source
Gastrointestinal tumor tissue
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
In vitro binding studies confirmed the presence of VIP receptors on gastrointestinal tumors.
Report a problemFND-0793563512

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

PepBank is a research reference. Talk to a doctor before you use any peptide.

Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors.

Summary

Results from this study13

Version history

Subjects

Publication types

MeSH terms