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Study · Non-randomized trial · n = 18 · 1994

7 results

Growth hormone treatment in growth-retarded adolescents after renal transplant.

Hokken-Koelega AC, Stijnen T, de Ridder MA, de Muinck Keizer-Schrama SM, Wolff ED, de Jong MC, Donckerwolcke RA, Groothoff JW, Blum WF, Drop SL

Lancet (London, England)1 May 1994Cited by 60 (Europe PMC)

PMID7910322 (opens in a new tab)DOI10.1016/s0140-6736(94)92465-1 (opens in a new tab)PepBankPUB-07910322
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In adolescents after renal transplant, bone maturation did not accelerate during GH treatment.

    In plain wordsIn adolescents after renal transplant, bone maturation did not accelerate during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeBone maturation
    Study

    n = 18

    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    4 or 8 IU per m2 per day (16 of 18 patients blindly assigned to one of the two doses) · 2 yearsAs given in this study (human).

    Source sentences

    Summary
    Bone maturation was not accelerated.
    4 context sentences
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.
  2. 02HumanNon-randomized trialEfficacy outcome

    In adolescents after renal transplant, glomerular filtration rate did not change significantly during GH treatment.

    In plain wordsIn adolescents after renal transplant, kidney filtration did not change significantly during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeGlomerular filtration rate
    Study

    n = 18

    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 or 8 IU per m2 per day (16 of 18 patients blindly assigned to one of the two doses) · 2 yearsAs given in this study (human).

    Source sentences

    Summary
    Glomerular filtration rate and effective renal plasma flow did not change significantly.
    4 context sentences
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.
  3. 03HumanNon-randomized trialEfficacy outcome

    In adolescents after renal transplant, effective renal plasma flow did not change significantly during GH treatment.

    In plain wordsIn adolescents after renal transplant, kidney plasma flow did not change significantly during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeEffective renal plasma flow
    Study

    n = 18

    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 or 8 IU per m2 per day (16 of 18 patients blindly assigned to one of the two doses) · 2 yearsAs given in this study (human).

    Source sentences

    Summary
    Glomerular filtration rate and effective renal plasma flow did not change significantly.
    4 context sentences
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.
  4. 04HumanNon-randomized trialSafety outcome

    In adolescents after renal transplant, some graft deterioration occurred, but the investigators found no relation with GH treatment.

    In plain wordsIn adolescents after renal transplant, some graft function worsened, but investigators found no link with GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeGraft function deterioration
    Study

    n = 18

    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 or 8 IU per m2 per day (16 of 18 patients blindly assigned to one of the two doses) · 2 yearsAs given in this study (human).

    Source sentences

    Summary
    Although a few patients had deterioration of graft function, we could not find a relation with GH treatment.
    4 context sentences
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.
  5. 05HumanNon-randomized trialEfficacy outcome

    In adolescents after renal transplant, growth results were similar between the two GH dose groups.

    In plain wordsIn adolescents after renal transplant, growth results were similar with the two GH doses.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeGrowth response by GH dose
    Study

    n = 16

    Comparator
    4 versus 8 IU per m2 per day
    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    4 or 8 IU per m2 per day · 2 yearsAs given in this study (human).

    Source sentences

    Summary
    Results were similar for the two GH dosage groups.
    4 context sentences
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.
  6. 06HumanNon-randomized trialEfficacy outcome

    In adolescents after renal transplant, GH-treated height gain was 15.7 (5.1) cm versus 5.8 (3.4) cm in matched controls (p < 0.0001).

    In plain wordsIn adolescents after renal transplant, height gain was greater with GH than in matched untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHeight increment versus matched controls
    Study

    n: not reported in source

    Comparator
    Matched non-GH-treated controls
    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    4 or 8 IU per m2 per day (16 of 18 patients blindly assigned to one of the two doses) · 2 yearsAs given in this study (human).

    Measurements

    Height increment
    15.7 cm
    GH mean
    Height increment SD
    5.1 cm
    GH
    Height increment
    5.8 cm
    controls mean
    Height increment SD
    3.4 cm
    controls

    Source sentences

    Summary
    Mean (standard deviation) increment in height after 2 years of GH was 15.7 (5.1) cm, significantly greater (p < 0.0001) than in matched controls, 5.8 (3.4) cm.
    4 context sentences
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.
  7. 07HumanNon-randomized trialSafety outcome

    In adolescents after renal transplant, major GFR reductions occurred in 39% with GH versus 32% without GH (p = 0.97).

    In plain wordsIn adolescents after renal transplant, major kidney filtration reductions did not differ significantly between GH-treated patients and untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMore than 25% GFR reduction
    Study

    n: not reported in source

    Comparator
    Non-GH-treated controls
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 or 8 IU per m2 per day (16 of 18 patients blindly assigned to one of the two doses) · 2 yearsAs given in this study (human).

    Measurements

    Incidence of >25% GFR reduction
    39%
    GH-treated patients over 2 years
    Incidence of >25% GFR reduction
    32%
    non-GH-treated controls over 2 years

    Source sentences

    Summary
    The incidence of a > 25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p = 0.97).
    4 context sentences
    Summary · context
    18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years.
    Summary · context
    All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A.
    Summary · context
    16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day).
    Summary · context
    Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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