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Study · In vitro (cells) · rat · 1993

6 results

A novel non-peptidyl growth hormone secretagogue.

Cheng K, Chan WW, Butler B, Wei L, Smith RG

Hormone research1 Jan 1993Cited by 35 (Europe PMC)

PMID7905455 (opens in a new tab)DOI10.1159/000183777 (opens in a new tab)PepBankPUB-07905455
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat primary pituitary cells, GHRP‑6 stimulated GH release with an EC50 of 10(-8) M.

    In plain wordsIn cells from rats, GHRP‑6 stimulated growth hormone release.

    Peptide
    GHRP-6
    Outcome
    Not applicableGH release EC50
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under the same conditions, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GH-releasing peptide, GHRP-6) and GH-releasing factor (GRF) had EC50 values of 10(-8) and 5 x 10(-10) M, respectively.
  2. 02LabIn vitro (cells)Mechanism

    In rat pituitary cells, GHRP‑6 alone had no effect on intracellular cAMP levels.

    In plain wordsIn cells from rats, GHRP‑6 alone did not change intracellular cAMP levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeIntracellular cAMP
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Like GHRP-6, L-692,429 alone had no effect on intracellular cAMP levels;
  3. 03LabIn vitro (cells)Activity measurement

    In rat pituitary cells, maximal GH release with GHRP‑6 was comparable to L-692,429.

    In plain wordsIn cells from rats, GHRP‑6 and L-692,429 produced comparable maximal growth hormone release.

    Peptide
    GHRP-6
    Outcome
    No significant changeMaximal GH release
    Study

    ratn: not reported in source

    Primary pituitary cells
    Comparator
    L-692,429
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Maximal effects of L-692,429 and GHRP-6 on GH release were comparable.
  4. 04LabIn vitro (cells)Activity measurement

    In rat pituitary cells, adding maximal GHRP‑6 to maximal L-692,429 did not increase GH release.

    In plain wordsIn cells from rats, adding GHRP‑6 to L-692,429 did not increase growth hormone release compared with L-692,429 alone.

    Peptide
    GHRP-6
    Outcome
    No significant changeCombined maximal GH release
    Study

    ratn: not reported in source

    Primary pituitary cells
    Comparator
    L-692,429 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, when presented together in maximal concentrations, L-692,429 and GHRP-6 did not cause an additional GH release when compared with either secretagogue alone.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat pituitary cells, L-692,400 inhibited the GH response to GHRP‑6.

    In plain wordsIn cells from rats, L-692,400 reduced the growth hormone response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response inhibition
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    L-692,400, which is structurally related to L-692,429 but biologically inactive, inhibited GH response not only to L-692,429 but also GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 06LabNot a test of GHRP-6 aloneIn vitro (cells)Activity measurement

    In rat pituitary cells, combined maximal L-692,429 and GHRP‑6 did not increase GH release versus GHRP‑6 alone.

    In plain wordsIn cells from rats, adding L-692,429 to GHRP‑6 did not increase growth hormone release compared with GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    No significant changeCombined maximal GH release
    Study

    ratn: not reported in source

    Primary pituitary cells
    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Interestingly, when presented together in maximal concentrations, L-692,429 and GHRP-6 did not cause an additional GH release when compared with either secretagogue alone.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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