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Study · Non-randomized trial · n = 9 · 1993

11 results

Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men.

Jaffe CA, Ho PJ, Demott-Friberg R, Bowers CY, Barkan AL

The Journal of clinical endocrinology and metabolism1 Dec 1993Cited by 40 (Europe PMC)

PMID7903313 (opens in a new tab)DOI10.1210/jcem.77.6.7903313 (opens in a new tab)PepBankPUB-07903313
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy young men, GHRP infusion increased integrated GH concentration versus saline.

    In plain wordsIn healthy young men, GHRP infusion increased overall growth hormone exposure versus saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntegrated GH concentration
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Measurements

    IGHC
    2908 micrograms x min/L
    GHRP
    IGHC
    1374 micrograms x min/L
    saline

    Source sentences

    Summary
    During GHRP infusion, there was a significant increase in IGHC (2908 +/- 450 vs. 1374 +/- 160 micrograms x min/L), maximum pulse amplitude (15.2 +/- 2.8 vs. 8.4 +/- 1.7 micrograms/L), and mean pulse amplitude (7.0 +/- 1.1 vs. 3.8 +/- 1.5 micrograms/L).
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy young men, GHRP infusion increased maximum GH pulse amplitude versus saline.

    In plain wordsIn healthy young men, GHRP increased the largest growth hormone pulse versus saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseMaximum GH pulse amplitude
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Measurements

    Maximum pulse amplitude
    15.2 micrograms/L
    GHRP
    Maximum pulse amplitude
    8.4 micrograms/L
    saline

    Source sentences

    Summary
    During GHRP infusion, there was a significant increase in IGHC (2908 +/- 450 vs. 1374 +/- 160 micrograms x min/L), maximum pulse amplitude (15.2 +/- 2.8 vs. 8.4 +/- 1.7 micrograms/L), and mean pulse amplitude (7.0 +/- 1.1 vs. 3.8 +/- 1.5 micrograms/L).
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy young men, GHRP infusion increased mean GH pulse amplitude versus saline.

    In plain wordsIn healthy young men, GHRP increased average growth hormone pulse size versus saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseMean GH pulse amplitude
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Measurements

    Mean pulse amplitude
    7 micrograms/L
    GHRP
    Mean pulse amplitude
    3.8 micrograms/L
    saline

    Source sentences

    Summary
    During GHRP infusion, there was a significant increase in IGHC (2908 +/- 450 vs. 1374 +/- 160 micrograms x min/L), maximum pulse amplitude (15.2 +/- 2.8 vs. 8.4 +/- 1.7 micrograms/L), and mean pulse amplitude (7.0 +/- 1.1 vs. 3.8 +/- 1.5 micrograms/L).
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy young men, plasma IGF-I increased from 252 to 312 micrograms/L during GHRP infusion.

    In plain wordsIn healthy young men, blood IGF-I increased during GHRP infusion.

    Peptide
    GHRP-6
    Outcome
    IncreasePlasma IGF-I
    Study

    n = 9

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Measurements

    IGF-I
    252 micrograms/L
    before
    IGF-I
    312 micrograms/L
    after

    Source sentences

    Summary
    Plasma insulin-like growth factor-I increased from 252 +/- 23 to 312 +/- 23 micrograms/L.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy young men, GHRP infusion did not change GH pulse frequency versus saline.

    In plain wordsIn healthy young men, GHRP did not change growth hormone pulse frequency versus saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH pulse frequency
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    There was no change in either GH pulse frequency or interpulse GH concentration.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  6. 06HumanNon-randomized trialEfficacy outcome

    In healthy young men, GHRP infusion did not change interpulse GH concentration versus saline.

    In plain wordsIn healthy young men, GHRP did not change growth hormone between pulses versus saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeInterpulse GH concentration
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    There was no change in either GH pulse frequency or interpulse GH concentration.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  7. 07HumanNon-randomized trialEfficacy outcome

    In healthy young men, GHRP infusion augmented GH responses to GHRH boluses versus saline infusion.

    In plain wordsIn healthy young men, GHRP infusion increased growth hormone responses to GHRH versus saline infusion.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRH boluses
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    During GHRP infusion, the GH responses to the GHRH boluses were augmented; however, baseline TSH was lower, and the GH and TSH/PRL responses to GHRP and TRH, respectively, were smaller.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  8. 08HumanNon-randomized trialEfficacy outcome

    In healthy young men, baseline TSH was lower during GHRP infusion than saline infusion.

    In plain wordsIn healthy young men, GHRP infusion lowered baseline thyroid-stimulating hormone versus saline infusion.

    Peptide
    GHRP-6
    Outcome
    DecreaseBaseline TSH
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    During GHRP infusion, the GH responses to the GHRH boluses were augmented; however, baseline TSH was lower, and the GH and TSH/PRL responses to GHRP and TRH, respectively, were smaller.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  9. 09HumanNon-randomized trialEfficacy outcome

    In healthy young men, GH responses to a GHRP bolus were smaller during GHRP infusion than saline infusion.

    In plain wordsIn healthy young men, a GHRP injection released less growth hormone during GHRP infusion than saline infusion.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response to GHRP bolus
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    During GHRP infusion, the GH responses to the GHRH boluses were augmented; however, baseline TSH was lower, and the GH and TSH/PRL responses to GHRP and TRH, respectively, were smaller.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  10. 10HumanNon-randomized trialEfficacy outcome

    In healthy young men, TSH responses to TRH were smaller during GHRP infusion than saline infusion.

    In plain wordsIn healthy young men, GHRP infusion reduced thyroid-stimulating hormone responses to TRH versus saline infusion.

    Peptide
    GHRP-6
    Outcome
    DecreaseTSH response to TRH
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    During GHRP infusion, the GH responses to the GHRH boluses were augmented; however, baseline TSH was lower, and the GH and TSH/PRL responses to GHRP and TRH, respectively, were smaller.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.
  11. 11HumanNon-randomized trialEfficacy outcome

    In healthy young men, prolactin responses to TRH were smaller during GHRP infusion than saline infusion.

    In plain wordsIn healthy young men, GHRP infusion reduced prolactin responses to TRH versus saline infusion.

    Peptide
    GHRP-6
    Outcome
    DecreaseProlactin response to TRH
    Study

    n = 9

    Comparator
    normal saline infusion
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microgram/kg loading bolus, then 1 microgram/kg.h · intravenous · 34 hAs given in this study (human).

    Source sentences

    Summary
    During GHRP infusion, the GH responses to the GHRH boluses were augmented; however, baseline TSH was lower, and the GH and TSH/PRL responses to GHRP and TRH, respectively, were smaller.
    2 context sentences
    Summary · context
    To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young men.
    Summary · context
    GHRP was given as a 1 microgram/kg loading bolus, then at the rate of 1 microgram/kg.h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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