Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.

Iwabuchi Y, Masuhara T

General pharmacology1 Nov 1994Cited by 2 (Europe PMC)

PMID7896056DOI10.1016/0306-3623(94)90169-4PepBankPUB-07896056

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rat submandibular glands, VIP enhanced the fluid secretion that noradrenaline mediates.
In plain wordsIn rats, VIP increased the fluid released by a salivary gland when noradrenaline was also present.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseNoradrenaline-mediated fluid secretion
Study
ratn: not reported in source
submandibular gland
Comparator
Noradrenaline alone
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP).
1 context sentence(design, population, supporting numbers)
Title · context
Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.
Report a problemFND-0789605601
02AnimalAnimal study (in vivo)Efficacy outcome
In rat submandibular glands, VIP enhanced the protein secretion that noradrenaline mediates.
In plain wordsIn rats, VIP increased the protein released by a salivary gland when noradrenaline was also present.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseNoradrenaline-mediated protein secretion
Study
ratn: not reported in source
submandibular gland
Comparator
Noradrenaline alone
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP).
1 context sentence(design, population, supporting numbers)
Title · context
Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.
Report a problemFND-0789605602

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

03AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In rat submandibular glands, pretreatment with prazosin or phentolamine antagonized the synergistic effect of VIP combined with noradrenaline.
In plain wordsIn rats, prazosin or phentolamine blocked the combined effect of VIP and noradrenaline on a salivary gland.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEffect of prazosin or phentolamine on the VIP and noradrenaline response
Study
ratn: not reported in source
submandibular gland
Comparator
No antagonist
Outcome group
Gastrointestinal function · Gastrointestinal
Source sentences
Summary
The synergistic effect of the combination of VIP with noradrenaline (NA) was antagonized by pretreatment with prazosin or phentolamine
1 context sentence(design, population, supporting numbers)
Title · context
Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0789605603
04AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In rat submandibular glands, pretreatment with yohimbine or propranolol did not antagonize the synergistic effect of VIP combined with noradrenaline.
In plain wordsIn rats, yohimbine or propranolol did not block the combined effect of VIP and noradrenaline on a salivary gland.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeEffect of yohimbine or propranolol on the VIP and noradrenaline response
Study
ratn: not reported in source
submandibular gland
Comparator
No antagonist
Outcome group
Gastrointestinal function · Gastrointestinal
Source sentences
Summary
The synergistic effect of the combination of VIP with noradrenaline (NA) was antagonized by pretreatment with prazosin or phentolamine but not by pretreatment with yohimbine or propranolol.
1 context sentence(design, population, supporting numbers)
Title · context
Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0789605604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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