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Study · Animal study (in vivo) · goat · 1995

9 results

Pharmacokinetics and bioactivity of intact versus truncated IGF-I during a 24-h infusion into lactating goats.

Prosser CG, Davis SR, Hodgkinson SC, Mohler MA

The Journal of endocrinology1 Jan 1995Cited by 6 (Europe PMC)

PMID7891029 (opens in a new tab)DOI10.1677/joe.0.1440099 (opens in a new tab)PepBankPUB-07891029
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In lactating goats, plasma IGF-I concentrations reached 640 +/- 32 ng/ml during des-IGF-I infusion versus 262 +/- 35 ng/ml with saline.

    In plain wordsIn goats, des-IGF-I infusion raised plasma IGF-I concentrations above saline infusion.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreasePlasma IGF-I concentration
    Study

    goatn = 5

    Lactating goats
    Comparator
    Saline infusion
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Measurements

    Plasma IGF-I
    640 ng/ml
    des-IGF-I infusion
    Plasma IGF-I
    262 ng/ml
    saline infusion

    Source sentences

    Summary
    Concentrations of IGF-I in plasma (from the jugular vein) rose rapidly during infusion of IGF-I or des-IGF-I to reach 510 +/- 62 and 640 +/- 32 ng/ml (mean +/- S.E.M.) respectively, compared with 262 +/- 35 ng/ml after a similar infusion of saline.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In lactating goats, des-IGF-I infusion increased IGF-I binding intensity at the BP-3 doublet compared with saline.

    In plain wordsIn goats, des-IGF-I infusion increased binding at BP-3 compared with saline.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBinding to BP-3 doublet
    Study

    goatn = 5

    Lactating goats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Source sentences

    Summary
    Ligand blotting analysis indicated a significant increase in the intensity of [125I]IGF-I binding to the 40-43 kDa doublet (binding protein-3 (BP-3), P < 0.01) and the band at 31 kDa (P < 0.05) during infusion of either IGF-I or des-IGF-I, as compared with saline.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In lactating goats, des-IGF-I infusion increased IGF-I binding intensity at the 31 kDa band compared with saline.

    In plain wordsIn goats, des-IGF-I increased binding at the 31 kDa band compared with saline.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBinding to 31 kDa band
    Study

    goatn = 5

    Lactating goats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Source sentences

    Summary
    Ligand blotting analysis indicated a significant increase in the intensity of [125I]IGF-I binding to the 40-43 kDa doublet (binding protein-3 (BP-3), P < 0.01) and the band at 31 kDa (P < 0.05) during infusion of either IGF-I or des-IGF-I, as compared with saline.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In lactating goats, des-IGF-I infusion significantly increased binding intensity at the 35 kDa band.

    In plain wordsIn goats, des-IGF-I infusion increased binding at the 35 kDa band.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBinding to 35 kDa band
    Study

    goatn = 5

    Lactating goats
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Source sentences

    Summary
    Furthermore des-IGF-I induced a significant increase in intensity of binding to the 35 and 24 kDa bands, but IGF-I did not.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In lactating goats, des-IGF-I infusion significantly increased binding intensity at the 24 kDa band.

    In plain wordsIn goats, des-IGF-I infusion increased binding at the 24 kDa band.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBinding to 24 kDa band
    Study

    goatn = 5

    Lactating goats
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Source sentences

    Summary
    Furthermore des-IGF-I induced a significant increase in intensity of binding to the 35 and 24 kDa bands, but IGF-I did not.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In lactating goats, mammary blood flow increased more during des-IGF-I infusion than IGF-I infusion after 12 h.

    In plain wordsIn goats, des-IGF-I increased mammary blood flow more than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMammary blood flow
    Study

    goatn = 5

    Lactating goats
    Comparator
    IGF-I infusion
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Measurements

    Mammary blood flow increase
    48%
    des-IGF-I after 12 h
    Mammary blood flow increase
    22%
    IGF-I after 12 h

    Source sentences

    Summary
    Mammary blood flow (MBF) increased 48 +/- 6% after 12 h of infusion of des-IGF-I, compared with an increase of 22 +/- 6% during IGF-I.
    2 context sentences
    Summary · context
    The difference in response was significant at P < 0.05.
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  7. 07AnimalAnimal study (in vivo)Pharmacokinetics

    In lactating goats receiving des-IGF-I, the infused mammary gland secreted more IGF-I into milk than the non-infused gland.

    In plain wordsIn goats receiving des-IGF-I, the infused gland secreted more IGF-I into milk than the other gland.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGF-I secretion into milk
    Study

    goatn = 5

    Lactating goats
    Comparator
    Non-infused mammary gland
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Source sentences

    Summary
    In addition, more IGF-I was secreted into the milk of the infused than the non-infused gland during either infusion of IGF-I or des-IGF-I.(ABSTRACT TRUNCATED AT 250 WORDS)
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).
  8. 08AnimalAnimal study (in vivo)Pharmacokinetics

    In lactating goats, plasma IGF-I reached 640 +/- 32 ng/ml during des-IGF-I infusion versus 510 +/- 62 ng/ml during intact IGF-I infusion.

    In plain wordsIn goats, plasma IGF-I concentrations were higher during des-IGF-I infusion than during intact IGF-I infusion.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreasePlasma IGF-I concentration versus intact IGF-I
    Study

    goatn = 5

    Lactating goats
    Comparator
    Intact IGF-I infusion
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · Pudic artery infusion · 24 hAs given in this study (goat).

    Measurements

    Plasma IGF-I
    640 ng/ml
    des-IGF-I infusion
    Plasma IGF-I
    510 ng/ml
    intact IGF-I infusion

    Source sentences

    Summary
    Concentrations of IGF-I in plasma (from the jugular vein) rose rapidly during infusion of IGF-I or des-IGF-I to reach 510 +/- 62 and 640 +/- 32 ng/ml (mean +/- S.E.M.) respectively, compared with 262 +/- 35 ng/ml after a similar infusion of saline.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 09LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cell-free)Mechanism

    In ligand binding tests, radiolabeled des-IGF-I bound exclusively to BP-3, whereas radiolabeled IGF-I distributed among BP-3 and other binding proteins.

    In plain wordsIn lab tests, labeled des-IGF-I bound only BP-3, unlike labeled IGF-I, which bound several proteins.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableBinding protein distribution
    Study

    n: not reported in source

    Ligand binding to plasma binding proteins
    Comparator
    Radiolabeled IGF-I
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Whereas [125I]IGF-I was distributed between BP-3 and the other binding proteins, [125I]des-IGF-I bound exclusively to BP-3.
    1 context sentence
    Summary · context
    Each peptide was infused for 24 h into the pudic artery supplying one mammary gland of lactating goats (n = 5).

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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