Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.

Popovic V, Damjanovic S, Micic D, Djurovic M, Dieguez C, Casanueva FF

The Journal of clinical endocrinology and metabolism1 Mar 1995Cited by 114 (Europe PMC)

PMID7883854DOI10.1210/jcem.80.3.7883854PepBankPUB-07883854

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialEfficacy outcome
Patients with hypothalamopituitary disconnection had significantly lower GHRP‑6-induced GH secretion than normal controls.
In plain wordsPatients with hypothalamopituitary disconnection released less growth hormone after GHRP‑6 than normal controls.
Peptide
GHRP-6
Outcome
DecreaseGH AUC versus normal controls
Study
n = 23
Comparator
Normal controls given GHRP-6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Measurements
GH AUC
97.3 micrograms per L/120 min
Disconnected patients after GHRP-6
GH AUC
1434.8 micrograms per L/120 min
Normal controls after GHRP-6
Source sentences
Summary
In the group of patients with hypothalamopituitary disconnection, the level of GH secreted after GHRH was similar to that in controls (423.4 +/- 62.8); however, a complete blockade was observed after GHRP-6 (97.3 +/- 7.9), significantly (P < 0.05) lower than after GHRH as well as lower than the GHRP…
Summary
1434.8 +/- 393.0 after GHRP-6
3 context sentences(design, population, supporting numbers)
Summary · context
Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied.
Summary · context
Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min).
Report a problemFND-0788385403
02HumanNon-randomized trialEfficacy outcome
In patients with hypothalamopituitary disconnection, GH secretion after GHRP‑6 was significantly lower than after GHRH.
In plain wordsIn patients with hypothalamopituitary disconnection, GHRP‑6 produced less growth hormone release than GHRH.
Peptide
GHRP-6
Outcome
DecreaseGH AUC versus GHRH in disconnected patients
Study
n = 12
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Measurements
GH AUC
97.3 micrograms per L/120 min
Disconnected patients after GHRP-6
GH AUC
423.4 micrograms per L/120 min
Disconnected patients after GHRH (comparator)
Source sentences
Summary
In the group of patients with hypothalamopituitary disconnection, the level of GH secreted after GHRH was similar to that in controls (423.4 +/- 62.8); however, a complete blockade was observed after GHRP-6 (97.3 +/- 7.9), significantly (P < 0.05) lower than after GHRH as well as lower than the GHRP…
3 context sentences(design, population, supporting numbers)
Summary · context
Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied.
Summary · context
Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min).
Report a problemFND-0788385402
03HumanNon-randomized trialEfficacy outcome
In normal controls, GHRP‑6 produced a GH AUC of 1434.8 micrograms per L/120 min.
In plain wordsIn normal controls, GHRP‑6 produced a growth hormone AUC of 1434.8 micrograms per L/120 min.
Peptide
GHRP-6
Outcome
Not applicableGH AUC in normal controls
Study
n = 11
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Measurements
GH AUC
1434.8 micrograms per L/120 min
Normal controls after GHRP-6
Source sentences
Summary
In normal subjects GH secretion was 483.7 +/- 99.2 after GHRH, 1434.8 +/- 393.0 after GHRP-6, and 3771.5 +/- 399.6 after GHRH plus GHRP-6;
3 context sentences(design, population, supporting numbers)
Summary · context
Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied.
Summary · context
Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min).
Report a problemFND-0788385401

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

04HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
Patients with hypothalamopituitary disconnection had reduced GH secretion after GHRH plus GHRP‑6 compared with controls.
In plain wordsPatients with hypothalamopituitary disconnection released less growth hormone after GHRH plus GHRP‑6 than normal controls.
Peptide
GHRP-6
Outcome
DecreaseCombination GH AUC versus controls
Study
n = 23
Comparator
Normal controls given GHRH plus GHRP-6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
745.3 micrograms per L/120 min
Disconnected patients after GHRH plus GHRP-6
GH AUC
3771.5 micrograms per L/120 min
Normal controls after GHRH plus GHRP-6
Source sentences
Summary
After GHRH plus GHRP-6, the patients with hypothalamopituitary disconnection showed severely reduced secretion (745.3 +/- 67.6; P < 0.01 vs. controls), a value that was not significantly different from the arithmetic addition of levels produced by both compounds administered separately.(ABSTRACT TRUNCATED AT 400 WORDS)
Summary
3771.5 +/- 399.6 after GHRH plus GHRP-6
3 context sentences(design, population, supporting numbers)
Summary · context
Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied.
Summary · context
Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0788385405
05HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In disconnected patients, GH secretion after GHRH plus GHRP‑6 did not significantly differ from the sum of separate responses.
In plain wordsIn disconnected patients, GHRH plus GHRP‑6 released similar growth hormone to the sum of responses to each drug alone.
Peptide
GHRP-6
Outcome
No significant changeCombination GH AUC versus summed responses in patients
Study
n = 12
Comparator
Arithmetic sum of responses to each compound alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
745.3 micrograms per L/120 min
Disconnected patients after GHRH plus GHRP-6
GH AUC
423.4 micrograms per L/120 min
Disconnected patients after GHRH alone
GH AUC
97.3 micrograms per L/120 min
Disconnected patients after GHRP-6 alone
Source sentences
Summary
After GHRH plus GHRP-6, the patients with hypothalamopituitary disconnection showed severely reduced secretion (745.3 +/- 67.6; P < 0.01 vs. controls), a value that was not significantly different from the arithmetic addition of levels produced by both compounds administered separately.(ABSTRACT TRUNCATED AT 400 WORDS)
Summary
the level of GH secreted after GHRH was similar to that in controls (423.4 +/- 62.8); however, a complete blockade was observed after GHRP-6 (97.3 +/- 7.9)
3 context sentences(design, population, supporting numbers)
Summary · context
Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied.
Summary · context
Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0788385406
06HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In normal controls, GHRH plus GHRP‑6 produced greater GH secretion than the arithmetic sum of separate responses.
In plain wordsIn normal controls, GHRH plus GHRP‑6 released more growth hormone than the sum of responses to each drug alone.
Peptide
GHRP-6
Outcome
IncreaseCombination GH AUC versus summed responses in controls
Study
n = 11
Comparator
Arithmetic sum of responses to each compound alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
3771.5 micrograms per L/120 min
Normal controls after GHRH plus GHRP-6
GH AUC
483.7 micrograms per L/120 min
Normal controls after GHRH alone
GH AUC
1434.8 micrograms per L/120 min
Normal controls after GHRP-6 alone
Source sentences
Summary
In normal subjects GH secretion was 483.7 +/- 99.2 after GHRH, 1434.8 +/- 393.0 after GHRP-6, and 3771.5 +/- 399.6 after GHRH plus GHRP-6; the level of GH secreted after GHRH plus GHRP-6 treatment was significantly (P < 0.05) higher than after the arithmetic sum of GH levels after both compounds adm…
3 context sentences(design, population, supporting numbers)
Summary · context
Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied.
Summary · context
Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6.
Summary · context
GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0788385404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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