Effect of GHRP-6 and GHRH on GH secretion in rats following chronic glucocorticoid treatment.

Voltz DM, Piering AW, Magestro M, Giustina A, Wehrenberg WB

Life sciences1 Jan 1995Cited by 14 (Europe PMC)

PMID7869829DOI10.1016/0024-3205(94)00478-bPepBankPUB-07869829

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In vehicle-treated rats, GHRP‑6 increased plasma GH above baseline in a dose-dependent manner.
In plain wordsIn rats given vehicle, GHRP‑6 increased growth hormone above baseline as the dose increased.
Peptide
GHRP-6
Outcome
IncreaseGH response in vehicle-treated rats
Study
ratn: not reported in source
Conscious freely-moving rats
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1, 4 and 25 micrograms/kg · intravenousAs given in this study (rat).
Source sentences
Summary
GHRP-6 increased plasma GH levels over baseline concentrations in a dose-dependent fashion both in vehicle- and dex-treated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were treated daily for seven days with either vehicle or dexamethasone (dex, 40 micrograms/day). On the day of experimentation, rats received an i.v. injection of saline or GHRP-6 followed 15 min later by an i.v. injection of saline or rat GHRH. Three doses of GHRP-6 were evaluated, 1 microg…
Report a problemFND-0786982901
02AnimalAnimal study (in vivo)Efficacy outcome
In dexamethasone-treated rats, GHRP‑6 increased plasma GH above baseline in a dose-dependent manner.
In plain wordsIn rats given dexamethasone, GHRP‑6 increased growth hormone above baseline as the dose increased.
Peptide
GHRP-6
Outcome
IncreaseGH response in dexamethasone-treated rats
Study
ratn: not reported in source
Conscious freely-moving rats
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1, 4 and 25 micrograms/kg · intravenousAs given in this study (rat).
Source sentences
Summary
GHRP-6 increased plasma GH levels over baseline concentrations in a dose-dependent fashion both in vehicle- and dex-treated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were treated daily for seven days with either vehicle or dexamethasone (dex, 40 micrograms/day). On the day of experimentation, rats received an i.v. injection of saline or GHRP-6 followed 15 min later by an i.v. injection of saline or rat GHRH. Three doses of GHRP-6 were evaluated, 1 microg…
Report a problemFND-0786982902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, the GH response to GHRP‑6 was significantly lower after dexamethasone treatment than after vehicle.
In plain wordsIn rats, GHRP‑6 produced a lower growth hormone response after dexamethasone treatment than after vehicle.
Peptide
GHRP-6
Outcome
DecreaseGH response under dexamethasone treatment
Study
ratn: not reported in source
Conscious freely-moving rats
Comparator
Vehicle-treated rats given GHRP-6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1, 4 and 25 micrograms/kg · intravenousAs given in this study (rat).
Source sentences
Summary
The GH response to GHRP-6 and GHRH was significantly less in dex-treated rats as compared to vehicle-treated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were treated daily for seven days with either vehicle or dexamethasone (dex, 40 micrograms/day). On the day of experimentation, rats received an i.v. injection of saline or GHRP-6 followed 15 min later by an i.v. injection of saline or rat GHRH. Three doses of GHRP-6 were evaluated, 1 microg…
Report a problemFND-0786982903

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In rats, GHRP‑6 plus GHRH produced no GH change beyond that predicted from either peptide alone.
In plain wordsIn rats, GHRP‑6 plus GHRH produced no growth hormone change beyond the response predicted from either peptide alone.
Peptide
GHRP-6
Outcome
No significant changeGH response additivity
Study
ratn: not reported in source
Conscious freely-moving rats
Comparator
Response predicted from either peptide alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The combined administration of GHRP-6 and GHRH did not result in any change in plasma GH levels which could not be predicted from the administration of either peptide alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were treated daily for seven days with either vehicle or dexamethasone (dex, 40 micrograms/day). On the day of experimentation, rats received an i.v. injection of saline or GHRP-6 followed 15 min later by an i.v. injection of saline or rat GHRH.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0786982904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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