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Study · Animal study (in vivo) · rat · 1994

2 results

Intracerebral microinjections of dermorphin: search for the epileptic induction thresholds.

Greco B, Prevost J, Gioanni Y

Neuroreport1 Oct 1994Cited by 10 (Europe PMC)

PMID7865769 (opens in a new tab)DOI10.1097/00001756-199410270-00045 (opens in a new tab)PepBankPUB-07865769
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats, dermorphin triggered epileptic discharges only in ventral hippocampal CA1 and CA3, amygdala and entorhinal cortex.

    In plain wordsIn rats, dermorphin triggered epileptic discharges only in the ventral hippocampus, amygdala and entorhinal cortex.

    Peptide
    Dermorphin
    Outcome
    IncreaseRegional epileptic discharges
    Study

    ratn: not reported in source

    Intracerebral microinjection
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    up to 6 nmol · intracerebralAs given in this study (rat).

    Source sentences

    Summary
    Epileptic discharges were triggered only in the ventral hippocampus (CA1 and CA3 areas), amygdala and entorhinal cortex.
    1 context sentence
    Summary · context
    The dose of dermorphin (up to 6 nmol) necessary to trigger electrical epileptic events in each of these regions was studied.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats, the dermorphin dose threshold for epileptic induction was lowest in ventral hippocampal CA1.

    In plain wordsIn rats, ventral hippocampal CA1 had the lowest dermorphin threshold for epileptic activity compared with other tested regions.

    Peptide
    Dermorphin
    Outcome
    DecreaseEpileptic induction threshold
    Study

    ratn: not reported in source

    Intracerebral microinjection
    Comparator
    Other tested brain regions
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    up to 6 nmol · intracerebralAs given in this study (rat).

    Source sentences

    Summary
    The epileptic induction threshold was the lowest in the CA1 area of the ventral hippocampus.
    1 context sentence
    Summary · context
    The dose of dermorphin (up to 6 nmol) necessary to trigger electrical epileptic events in each of these regions was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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