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Study · Animal study (in vivo) · rat · 1994

6 results

Effect of D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats.

Sawada H, Sugihara H, Onose H, Minami S, Shibasaki T, Wakabayashi I

Regulatory peptides1 Oct 1994Cited by 6 (Europe PMC)

PMID7846295 (opens in a new tab)DOI10.1016/0167-0115(94)90168-6 (opens in a new tab)PepBankPUB-07846295
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In urethan-anesthetized rats, KP-102 alone exerted only a small influence on GH secretion.

    In plain wordsIn anesthetized rats, KP-102 alone had only a small effect on growth hormone release.

    Peptide
    GHRP-2
    Outcome
    Direction not reportedPlasma GH response to KP-102 alone
    Study

    ratn: not reported in source

    Urethan-anesthetized adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although KP-102 alone exerted a small influence on GH secretion
    1 context sentence
    Summary · context
    The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In urethan-anesthetized rats during continuous GRF infusion, somatotropes became refractory to a large GRF bolus, but KP-102 induced a marked increase of plasma GH.

    In plain wordsIn anesthetized rats whose GH cells no longer responded to GRF, KP-102 still caused a marked rise in growth hormone.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH response to KP-102 during continuous GRF infusion
    Study

    ratn: not reported in source

    Urethan-anesthetized adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    During the continuous infusion of GRF, the somatotropes became refractory to a large bolus dose of GRF, but KP-102 induced a marked increase of plasma GH.
    1 context sentence
    Summary · context
    The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats.

Studies that did not test the peptide alone4

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 03AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In urethan-anesthetized rats, KP-102 produced a large plasma GH response in the presence of exogenous GRF.

    In plain wordsIn anesthetized rats, KP-102 given with GRF produced a large growth hormone response.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH response to KP-102 with exogenous GRF
    Study

    ratn: not reported in source

    Urethan-anesthetized adult male rats
    Comparator
    KP-102 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    it produced a large plasma GH response in the presence of exogenous GH-releasing factor (GRF).
    1 context sentence
    Summary · context
    The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In rats, the GH response to KP-102 alone or with GRF was significantly augmented by prior antiserum to somatostatin.

    In plain wordsIn rats, blocking somatostatin beforehand made the growth hormone response to KP-102 larger.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to KP-102 after somatostatin antiserum
    Study

    ratn: not reported in source

    Urethan-anesthetized adult male rats
    Comparator
    No antiserum
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The GH response to KP-102 alone or KP-102 with GRF was significantly augmented when antiserum to somatostatin (ASS) was previously administered.
    1 context sentence
    Summary · context
    The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  3. 05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In rats, KP-102 and GRF acted synergistically on GH secretion in control animals and additively in antiserum-treated rats.

    In plain wordsIn rats, KP-102 and GRF worked synergistically on growth hormone release in controls, but only additively after somatostatin antiserum.

    Peptide
    GHRP-2
    Outcome
    MixedInteraction of KP-102 and GRF in control versus antiserum rats
    Study

    ratn: not reported in source

    Urethan-anesthetized adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Although KP-102 and GRF acted synergistically on GH secretion in control animals, they acted additively in ASS-administered rats.
    1 context sentence
    Summary · context
    The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  4. 06AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In rats, the KP-102 effect on plasma GH was significantly attenuated by prior i.v. antiserum to GRF.

    In plain wordsIn rats, blocking GRF with an antiserum beforehand reduced the growth hormone response to KP-102.

    Peptide
    GHRP-2
    Outcome
    DecreaseKP-102 effect on plasma GH after GRF antiserum
    Study

    ratn: not reported in source

    Urethan-anesthetized adult male rats
    Comparator
    No GRF antiserum
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The KP-102 effect on plasma GH was significantly attenuated in control animals and ASS-administered rats by prior i.v. injection of antiserum to GRF.
    1 context sentence
    Summary · context
    The effect of a newly developed growth hormone (GH)-releasing hexapeptide (KP-102) on GH secretion was studied in urethan-anesthetized adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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