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Study · Randomized controlled trial · n = 44 · 1994

7 results

Prevention of further bone mass loss by nasal calcitonin in patients on long term glucocorticoid therapy for asthma: a two year follow up study.

Luengo M, Pons F, Martinez de Osaba MJ, Picado C

Thorax1 Nov 1994Cited by 52 (Europe PMC)

PMID7831624 (opens in a new tab)PMCIDPMC475269 (opens in a new tab)DOI10.1136/thx.49.11.1099 (opens in a new tab)PepBankPUB-07831624
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In steroid-dependent asthmatic patients, calcitonin increased bone mass by 2.7% versus a 2.8% decrease with calcium alone.

    In plain wordsIn steroid-dependent asthma, calcitonin increased bone mass compared with calcium alone.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseSpinal bone mass in first year
    Study

    n = 44

    Comparator
    Calcium alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Measurements

    Bone mass change, first year
    2.7%
    salmon calcitonin nasal spray plus calcium
    Bone mass change, first year
    −2.8%
    calcium alone

    Source sentences

    Summary
    The bone mass in the calcitonin group increased by 2.7% in the first year while in the group receiving calcium alone it decreased by 2.8%; this difference was significant.
    1 context sentence
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.
  2. 02HumanRandomized controlled trialSafety outcome

    In steroid-dependent asthmatic patients, five patients in each group withdrew during the second year.

    In plain wordsFive patients in each treatment group withdrew during the second year.

    Peptide
    Calcitonin-salmon
    Outcome
    Not applicableSecond-year withdrawal
    Study

    n = 44

    Comparator
    Calcium alone
    Outcome group
    Adverse events · Whole body
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Measurements

    Second-year dropouts
    5 patients
    calcitonin group
    Second-year dropouts
    5 patients
    calcium alone group

    Source sentences

    Summary
    Five patients in each group dropped out during the second year.
    2 context sentences
    Summary · context
    In the calcitonin group one patient developed generalised pruritus and four lost steroid dependence, and in the calcium alone group five were no longer dependent on steroids.
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In steroid-dependent asthmatic patients, four in the calcitonin group lost steroid dependence, compared with five in the calcium-alone group.

    In plain wordsFour calcitonin patients and five calcium-only patients no longer depended on steroids.

    Peptide
    Calcitonin-salmon
    Outcome
    Not applicableLoss of steroid dependence
    Study

    n = 44

    Comparator
    Calcium alone
    Outcome group
    Steroid dependence · Respiratory
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Measurements

    Patients who lost steroid dependence
    4 patients
    calcitonin group
    Patients who lost steroid dependence
    5 patients
    calcium alone group

    Source sentences

    Summary
    In the calcitonin group one patient developed generalised pruritus and four lost steroid dependence, and in the calcium alone group five were no longer dependent on steroids.
    1 context sentence
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In steroid-dependent asthmatic patients, calcitonin prevented more second-year bone loss than calcium alone; the difference between means was 0.1077 (95% CI 0.0381 to 0.1773).

    In plain wordsIn steroid-dependent asthma, calcitonin prevented more second-year bone loss than calcium alone.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseBone loss in second year
    Study

    n: not reported in source

    Comparator
    Calcium alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Measurements

    Bone mass change, second year
    −7.8%
    calcium alone group
    Difference between means
    0.1077
    calcitonin versus calcium alone
    95% CI of difference between means
    0.0381 to 0.1773
    calcitonin versus calcium alone

    Source sentences

    Summary
    Calcitonin prevented more bone loss during the second year while the calcium alone group continued losing bone mass (-7.8%).
    2 context sentences
    Summary · context
    The difference between means was 0.1077 (95% CI 0.0381 to 0.1773).
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In steroid-dependent asthmatic patients, three new fractures occurred in each treatment group.

    In plain wordsThree new fractures occurred in each treatment group.

    Peptide
    Calcitonin-salmon
    Outcome
    Not applicableNew fractures
    Study

    n: not reported in source

    Comparator
    Calcium alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Measurements

    New fractures
    3 fractures
    calcitonin group
    New fractures
    3 fractures
    calcium alone group

    Source sentences

    Summary
    Three new fractures occurred in both groups.
    1 context sentence
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In steroid-dependent asthmatic patients, biochemical parameters did not change in either treatment group.

    In plain wordsBone turnover blood markers did not change in either treatment group.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeBiochemical bone turnover parameters
    Study

    n: not reported in source

    Comparator
    Calcium alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Source sentences

    Summary
    No changes in biochemical parameters were detected in either group.
    1 context sentence
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.
  7. 07HumanNon-randomized trialSafety outcome

    In steroid-dependent asthmatic patients receiving calcitonin, one patient developed generalised pruritus.

    In plain wordsOne patient receiving calcitonin developed widespread itching.

    Peptide
    Calcitonin-salmon
    Outcome
    Not applicableGeneralised pruritus
    Study

    n = 22

    Outcome group
    Adverse events · Skin and wound
    Studied dose
    200 IU every other day · intranasal · 2 yearsAs given in this study (human).

    Measurements

    Patients with generalised pruritus
    1 patients
    calcitonin group

    Source sentences

    Summary
    In the calcitonin group one patient developed generalised pruritus and four lost steroid dependence, and in the calcium alone group five were no longer dependent on steroids.
    1 context sentence
    Summary · context
    All patients received a calcium supplement of 1000 mg and were allocated randomly into two groups treated with either salmon calcitonin nasal spray (200 IU every other day, n = 22) or calcium alone (n = 22) for two years.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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